| http://purl.uniprot.org/citations/31435991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31435991 | http://www.w3.org/2000/01/rdf-schema#comment | "Glutamine dependence is a unique metabolic defect seen in cutaneous melanoma (CM), directly influencing the treatment and prognosis. Here, we investigated the associations between 6025 common single-nucleotide polymorphisms (SNPs) in 77 glutamine metabolic pathway genes with CM-specific survival (CMSS) using genotyping datasets from two published genome-wide association studies (GWASs). In the single-locus analysis, 76 SNPs were found to be significantly associated with CMSS (P < .050, false-positive report probability < 0.2 and Bayesian false discovery probability < 0.8) in the discovery dataset, of which seven SNPs were replicated in the validation dataset and three SNPs (HAL rs17676826T > C, LGSN rs12663017T > A, and NOXRED1 rs8012548A > G) independently predicted CMSS, with an effect-allele attributed adjusted hazards ratio of 1.52 (95% confidence interval = 1.19-1.93) and P < .001, 0.68 (0.54-0.87) and P = .002 and 0.62 (0.46-0.83) and P = .002, respectively. The model including the number of unfavorable genotypes (NUGs) of these three SNPs and covariates improved the five-year CMSS prediction (P = .012) than the one with other covariates only. Further expression quantitative trait loci (eQTL) analysis found that the LGSN rs12663017 A allele was significantly associated with increased messenger RNA (mRNA) expression levels (P = 8.89 × 10 -11 ) in lymphoblastoid cell lines of the 1000 Genomes Project database. In the analysis of the genotype tissue expression (GTEx) project datasets, HAL rs17676826 C and NOXRED1 rs8012548 G alleles were significantly associated with their mRNA expression levels in sun-exposed skin of the lower leg (P = 6.62 × 10-6 and 1.37 × 10-7 , respectively) and in sun-not-exposed suprapubic skin (P < .001 and 1.43 × 10-8 , respectively). Taken together, these genetic variants of glutamine-metabolic pathway genes may be promising predictors of survival in patients with CM."xsd:string |
| http://purl.uniprot.org/citations/31435991 | http://purl.org/dc/terms/identifier | "doi:10.1002/mc.23100"xsd:string |
| http://purl.uniprot.org/citations/31435991 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/31435991 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/31435991 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/31435991 | http://purl.uniprot.org/core/author | "Chen K."xsd:string |
| http://purl.uniprot.org/citations/31435991 | http://purl.uniprot.org/core/author | "Wei Q."xsd:string |
| http://purl.uniprot.org/citations/31435991 | http://purl.uniprot.org/core/author | "Lee J.E."xsd:string |
| http://purl.uniprot.org/citations/31435991 | http://purl.uniprot.org/core/author | "Amos C.I."xsd:string |
| http://purl.uniprot.org/citations/31435991 | http://purl.uniprot.org/core/author | "Nan H."xsd:string |
| http://purl.uniprot.org/citations/31435991 | http://purl.uniprot.org/core/author | "Bloomer W."xsd:string |
| http://purl.uniprot.org/citations/31435991 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31435991 | http://purl.uniprot.org/core/name | "Mol Carcinog"xsd:string |
| http://purl.uniprot.org/citations/31435991 | http://purl.uniprot.org/core/pages | "2091-2103"xsd:string |
| http://purl.uniprot.org/citations/31435991 | http://purl.uniprot.org/core/title | "Genetic variants in glutamine metabolic pathway genes predict cutaneous melanoma-specific survival."xsd:string |
| http://purl.uniprot.org/citations/31435991 | http://purl.uniprot.org/core/volume | "58"xsd:string |
| http://purl.uniprot.org/citations/31435991 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31435991 |
| http://purl.uniprot.org/citations/31435991 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31435991 |
| http://purl.uniprot.org/uniprot/#_B4DLH8-mappedCitation-31435991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31435991 |
| http://purl.uniprot.org/uniprot/#_Q2PH55-mappedCitation-31435991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31435991 |
| http://purl.uniprot.org/uniprot/#_Q2PH56-mappedCitation-31435991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31435991 |
| http://purl.uniprot.org/uniprot/#_Q2PH57-mappedCitation-31435991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31435991 |
| http://purl.uniprot.org/uniprot/#_Q2PH58-mappedCitation-31435991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31435991 |
| http://purl.uniprot.org/uniprot/#_Q2PH59-mappedCitation-31435991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31435991 |