| http://purl.uniprot.org/citations/31439631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31439631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31439631 | http://www.w3.org/2000/01/rdf-schema#comment | "GIGYF (Grb10-interacting GYF [glycine-tyrosine-phenylalanine domain]) proteins coordinate with 4EHP (eIF4E [eukaryotic initiation factor 4E] homologous protein), the DEAD (Asp-Glu-Ala-Asp)-box helicase Me31B/DDX6, and mRNA-binding proteins to elicit transcript-specific repression. However, the underlying molecular mechanism remains unclear. Here, we report that GIGYF contains a motif necessary and sufficient for direct interaction with Me31B/DDX6. A 2.4 Å crystal structure of the GIGYF-Me31B complex reveals that this motif arranges into a coil connected to a β hairpin on binding to conserved hydrophobic patches on the Me31B RecA2 domain. Structure-guided mutants indicate that 4EHP-GIGYF-DDX6 complex assembly is required for tristetraprolin-mediated down-regulation of an AU-rich mRNA, thus revealing the molecular principles of translational repression."xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.329219.119"xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.329219.119"xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/author | "Izaurralde E."xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/author | "Izaurralde E."xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/author | "Bawankar P."xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/author | "Bawankar P."xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/author | "Helms S."xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/author | "Helms S."xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/author | "Igreja C."xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/author | "Igreja C."xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/author | "Peter D."xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/author | "Peter D."xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/author | "Ruscica V."xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/author | "Ruscica V."xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/author | "Valkov E."xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/author | "Valkov E."xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/author | "Weber R."xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/author | "Weber R."xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/31439631 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |