| http://purl.uniprot.org/citations/31444298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31444298 | http://www.w3.org/2000/01/rdf-schema#comment | "Voltage-dependent potassium channels (Kvs) gate in response to changes in electrical membrane potential by coupling a voltage-sensing module with a K+-selective pore. Animal toxins targeting Kvs are classified as pore blockers, which physically plug the ion conduction pathway, or as gating modifiers, which disrupt voltage sensor movements. A third group of toxins blocks K+ conduction by an unknown mechanism via binding to the channel turrets. Here, we show that Conkunitzin-S1 (Cs1), a peptide toxin isolated from cone snail venom, binds at the turrets of Kv1.2 and targets a network of hydrogen bonds that govern water access to the peripheral cavities that surround the central pore. The resulting ectopic water flow triggers an asymmetric collapse of the pore by a process resembling that of inherent slow inactivation. Pore modulation by animal toxins exposes the peripheral cavity of K+ channels as a novel pharmacological target and provides a rational framework for drug design."xsd:string |
| http://purl.uniprot.org/citations/31444298 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1908903116"xsd:string |
| http://purl.uniprot.org/citations/31444298 | http://purl.uniprot.org/core/author | "Dym O."xsd:string |
| http://purl.uniprot.org/citations/31444298 | http://purl.uniprot.org/core/author | "Frolow F."xsd:string |
| http://purl.uniprot.org/citations/31444298 | http://purl.uniprot.org/core/author | "Gordon D."xsd:string |
| http://purl.uniprot.org/citations/31444298 | http://purl.uniprot.org/core/author | "Panyi G."xsd:string |
| http://purl.uniprot.org/citations/31444298 | http://purl.uniprot.org/core/author | "Karbat I."xsd:string |
| http://purl.uniprot.org/citations/31444298 | http://purl.uniprot.org/core/author | "Gurevitz M."xsd:string |
| http://purl.uniprot.org/citations/31444298 | http://purl.uniprot.org/core/author | "Reuveny E."xsd:string |
| http://purl.uniprot.org/citations/31444298 | http://purl.uniprot.org/core/author | "Hamer-Rogotner S."xsd:string |
| http://purl.uniprot.org/citations/31444298 | http://purl.uniprot.org/core/author | "Szanto T."xsd:string |
| http://purl.uniprot.org/citations/31444298 | http://purl.uniprot.org/core/author | "Fine S."xsd:string |
| http://purl.uniprot.org/citations/31444298 | http://purl.uniprot.org/core/author | "Altman-Gueta H."xsd:string |
| http://purl.uniprot.org/citations/31444298 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31444298 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/31444298 | http://purl.uniprot.org/core/pages | "18700-18709"xsd:string |
| http://purl.uniprot.org/citations/31444298 | http://purl.uniprot.org/core/title | "Pore-modulating toxins exploit inherent slow inactivation to block K+ channels."xsd:string |
| http://purl.uniprot.org/citations/31444298 | http://purl.uniprot.org/core/volume | "116"xsd:string |
| http://purl.uniprot.org/citations/31444298 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31444298 |
| http://purl.uniprot.org/citations/31444298 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31444298 |
| http://purl.uniprot.org/uniprot/#_P0C1X2-mappedCitation-31444298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31444298 |
| http://purl.uniprot.org/uniprot/#_B7Z0Z2-mappedCitation-31444298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31444298 |
| http://purl.uniprot.org/uniprot/#_M9MSE4-mappedCitation-31444298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31444298 |
| http://purl.uniprot.org/uniprot/#_M9MSE6-mappedCitation-31444298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31444298 |