| http://purl.uniprot.org/citations/31445025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31445025 | http://www.w3.org/2000/01/rdf-schema#comment | "AimsHsa_circ_0007534 has been reported to be a novel cancer-related circRNA affecting multiple cancers. However, little is known about the role of hsa_circ_0007534 in cervical cancer specifically. In the current study, we aimed to explore the expression and function of hsa_circ_0007534 in cervical cancer.Main methodsThe expression of circRNA, miRNA and mRNA was measured using real-time quantitative polymerase chain reactions. Protein expression was assessed by Western blot. Knockdown of has_circ_0007534 was achieved by siRNA-mediated gene silencing. Cell proliferation was determined using a cell counting kit-8 and colony formation assays. Cell invasion was assessed using a Transwell invasion assay. RNA interactions were measured using an RNA pull-down and dual-luciferase reporter assays.Key findingsThe expression of hsa_circ_0007534 was upregulated in cervical cancer tissues and cell lines. Depletion of hsa_circ_0007534 decreased both the proliferation and invasion of cervical cancer cells. MicroRNA-498 (miR-498) was identified as a target of the miRNA encoded by hsa_circ_0007534. Levels of miR-498 were decreased in cervical cancer tissues, a finding that was inversely correlated with hsa_circ_0007534 expression. miR-498 overexpression repressed the proliferation and invasion of cervical cancer cells. B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) was verified as a target gene of miR-498. BMI-1 overexpression reversed the effects of hsa_circ_0007534 depletion or miR-498 overexpression on cervical cancer cell proliferation and invasion.SignificanceOur study demonstrates that downregulation of hsa_circ_0007534 represses the proliferation and invasion of cervical cancer through regulating the miR-498/BMI-1 axis, suggesting the hsa_circ_0007534/miR-498/BMI-1 axis as a potential therapeutic target to treat cervical cancer."xsd:string |
| http://purl.uniprot.org/citations/31445025 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.lfs.2019.116785"xsd:string |
| http://purl.uniprot.org/citations/31445025 | http://purl.uniprot.org/core/author | "Guo J."xsd:string |
| http://purl.uniprot.org/citations/31445025 | http://purl.uniprot.org/core/author | "Gao W."xsd:string |
| http://purl.uniprot.org/citations/31445025 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/31445025 | http://purl.uniprot.org/core/author | "Rong X."xsd:string |
| http://purl.uniprot.org/citations/31445025 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31445025 | http://purl.uniprot.org/core/name | "Life Sci"xsd:string |
| http://purl.uniprot.org/citations/31445025 | http://purl.uniprot.org/core/pages | "116785"xsd:string |
| http://purl.uniprot.org/citations/31445025 | http://purl.uniprot.org/core/title | "Downregulation of hsa_circ_0007534 restricts the proliferation and invasion of cervical cancer through regulating miR-498/BMI-1 signaling."xsd:string |
| http://purl.uniprot.org/citations/31445025 | http://purl.uniprot.org/core/volume | "235"xsd:string |
| http://purl.uniprot.org/citations/31445025 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31445025 |
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