| http://purl.uniprot.org/citations/31447178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31447178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31447178 | http://www.w3.org/2000/01/rdf-schema#comment | "TRPA1 is a chemosensory ion channel that functions as a sentinel for structurally diverse electrophilic irritants. Channel activation occurs through an unusual mechanism involving covalent modification of cysteine residues clustered within an amino-terminal cytoplasmic domain. Here, we describe a peptidergic scorpion toxin (WaTx) that activates TRPA1 by penetrating the plasma membrane to access the same intracellular site modified by reactive electrophiles. WaTx stabilizes TRPA1 in a biophysically distinct active state characterized by prolonged channel openings and low Ca2+ permeability. Consequently, WaTx elicits acute pain and pain hypersensitivity but fails to trigger efferent release of neuropeptides and neurogenic inflammation typically produced by noxious electrophiles. These findings provide a striking example of convergent evolution whereby chemically disparate animal- and plant-derived irritants target the same key allosteric regulatory site to differentially modulate channel activity. WaTx is a unique pharmacological probe for dissecting TRPA1 function and its contribution to acute and persistent pain."xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2019.07.014"xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2019.07.014"xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/author | "King G.F."xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/author | "King G.F."xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/author | "Julius D."xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/author | "Julius D."xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/author | "Medzihradszky K.F."xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/author | "Medzihradszky K.F."xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/author | "Herzig V."xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/author | "Herzig V."xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/author | "Kelly M.J.S."xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/author | "Kelly M.J.S."xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/author | "Emrick J.J."xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/author | "Emrick J.J."xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/author | "Lin King J.V."xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/author | "Lin King J.V."xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/pages | "1362-1374"xsd:string |
| http://purl.uniprot.org/citations/31447178 | http://purl.uniprot.org/core/pages | "1362-1374"xsd:string |