| http://purl.uniprot.org/citations/31455213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31455213 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundA study has shown that miR-423-5p is highly expressed in proliferative diabetic retinopathy. However, the exact biological functions and mechanisms of miR-423-5p in diabetic retinopathy (DR) progression are currently unclear. This study aimed to investigate the role of miR-423-5p in DR and the underlying mechanism.ResultsOur data demonstrate that the expression of miR-423-5p is significantly increased in HG-induced RPE cells and DR patient plasma. Moreover, the overexpression of miR-423-5p exacerbates HG-induced apoptosis. Mechanistically, our results provide evidence that miR-423-5p directly targets TFF1. MiR-423-5p exerts its effect on HG-induced apoptosis in RPE cells through TFF1, and the NF-κB pathway is involved in the regulatory mechanism. Further analysis revealed that the transcription factor NFE2 regulates miR-423-5p promoter activity. In addition, NFE2 regulates the levels of TFF1 and NF-κB pathway-associated proteins by regulating the expression of miR-423-5p.ConclusionThe NFE2-miR-423-5p-TFF1 axis is a novel molecular mechanism and provides a new direction for the study and treatment of DR."xsd:string |
| http://purl.uniprot.org/citations/31455213 | http://purl.org/dc/terms/identifier | "doi:10.1186/s12860-019-0223-2"xsd:string |
| http://purl.uniprot.org/citations/31455213 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/31455213 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/31455213 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/31455213 | http://purl.uniprot.org/core/author | "Xiao Q."xsd:string |
| http://purl.uniprot.org/citations/31455213 | http://purl.uniprot.org/core/author | "Li W.J."xsd:string |
| http://purl.uniprot.org/citations/31455213 | http://purl.uniprot.org/core/author | "Sun H.J."xsd:string |
| http://purl.uniprot.org/citations/31455213 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31455213 | http://purl.uniprot.org/core/name | "BMC Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/31455213 | http://purl.uniprot.org/core/pages | "39"xsd:string |
| http://purl.uniprot.org/citations/31455213 | http://purl.uniprot.org/core/title | "NFE2/miR-423-5p/TFF1 axis regulates high glucose-induced apoptosis in retinal pigment epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/31455213 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/31455213 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31455213 |
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