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http://purl.uniprot.org/citations/31461407http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31461407http://www.w3.org/2000/01/rdf-schema#comment"

Background

There is an increasing concern about age-related frailty because of the growing number of elderly people in the general population. The Longevity-Associated Variant (LAV) of the human BPIFB4 gene was found to correct endothelial dysfunction, one of the mechanisms underlying frailty, in aging mice whereas the RV-BPIFB4 variant induced opposite effects. Thus, we newly hypothesize that, besides being associated with life expectancy, BPIFB4 polymorphisms can predict frailty.Aim and Results: Here we investigated if the BPIFB4 haplotypes, LAV, wild-type (WT) and RV, differentially associate with frailty in a cohort of 237 elderly subjects from Calabria region in Southern Italy. Moreover, we studied the effect of systemic adeno-associated viral vector-mediated LAV-BPIFB4 gene transfer on the progression of frailty in aging mice. We found an inverse correlation of the homozygous LAV-BPIFB4 haplotype with frailty in elderly subjects. Conversely, carriers of the RV-BPIFB4 haplotype showed an increase in the frailty status and risk of death. Moreover, in old mice, LAV-BPIFB4 gene transfer delayed frailty progression.

Conclusions

These data indicate that specific BPIFB4 haplotypes could represent useful genetic markers of frailty. In addition, horizontal transfer of a healthy gene variant can attenuate frailty in aging organisms."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.org/dc/terms/identifier"doi:10.18632/aging.102209"xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/author"Rose G."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/author"Basso A."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/author"Puca A.A."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/author"Maciag A."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/author"Villa F."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/author"Ciaglia E."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/author"Orlando F."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/author"Passarino G."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/author"Madeddu P."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/author"Vecchione C."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/author"Provinciali M."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/author"Dato S."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/author"Malavolta M."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/author"Iannone F."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/author"Ferrario A."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/author"Carrizzo A."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/author"D'amato A."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/author"Rango F."xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/name"Aging (Albany NY)"xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/pages"6555-6568"xsd:string
http://purl.uniprot.org/citations/31461407http://purl.uniprot.org/core/title"LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice."xsd:string
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