| http://purl.uniprot.org/citations/31461644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31461644 | http://www.w3.org/2000/01/rdf-schema#comment | "Generation of neuronal types at the right time, location, and number is essential for building a functional nervous system. Significant progress has been reached in understanding the mechanisms that govern neuronal diversity. Cerebrospinal fluid-contacting neurons (CSF-cNs), an intriguing spinal cord central canal population, are produced during advanced developmental stages, simultaneous with glial and ependymal cells. It is unknown how CSF-cNs are specified after the neurogenesis-to-gliogenesis switch. Here, we identify delayed Ascl1 expression in mouse spinal progenitors during the gliogenic phase as key in CSF-cN differentiation. With fate mappings and time-controlled deletions, we demonstrate that CSF-cNs derive from Ascl1-expressing cells and that Ascl1 triggers late neurogenesis in the amniote spinal cord. Ascl1 abrogation transforms prospective CSF-cN progenitors into ependymocytes. These results demonstrate that late spinal progenitors have the potential to produce neurons and that Ascl1 initiates CSF-cN differentiation, controlling the precise neuronal and nonneuronal composition of the spinal central canal."xsd:string |
| http://purl.uniprot.org/citations/31461644 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2019.07.087"xsd:string |
| http://purl.uniprot.org/citations/31461644 | http://purl.uniprot.org/core/author | "Hammerschmidt M."xsd:string |
| http://purl.uniprot.org/citations/31461644 | http://purl.uniprot.org/core/author | "Siegel N."xsd:string |
| http://purl.uniprot.org/citations/31461644 | http://purl.uniprot.org/core/author | "Lohr H."xsd:string |
| http://purl.uniprot.org/citations/31461644 | http://purl.uniprot.org/core/author | "Carcagno A.L."xsd:string |
| http://purl.uniprot.org/citations/31461644 | http://purl.uniprot.org/core/author | "Lanuza G.M."xsd:string |
| http://purl.uniprot.org/citations/31461644 | http://purl.uniprot.org/core/author | "Di Bella D.J."xsd:string |
| http://purl.uniprot.org/citations/31461644 | http://purl.uniprot.org/core/author | "Marin-Burgin A."xsd:string |
| http://purl.uniprot.org/citations/31461644 | http://purl.uniprot.org/core/author | "Pardi M.B."xsd:string |
| http://purl.uniprot.org/citations/31461644 | http://purl.uniprot.org/core/author | "Bartolomeu M.L."xsd:string |
| http://purl.uniprot.org/citations/31461644 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31461644 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/31461644 | http://purl.uniprot.org/core/pages | "2264-2274.e3"xsd:string |
| http://purl.uniprot.org/citations/31461644 | http://purl.uniprot.org/core/title | "Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal."xsd:string |
| http://purl.uniprot.org/citations/31461644 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/31461644 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31461644 |
| http://purl.uniprot.org/citations/31461644 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31461644 |
| http://purl.uniprot.org/uniprot/#_A0A087WNT5-mappedCitation-31461644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31461644 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SWF9-mappedCitation-31461644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31461644 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RM76-mappedCitation-31461644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31461644 |
| http://purl.uniprot.org/uniprot/#_D3YY51-mappedCitation-31461644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31461644 |
| http://purl.uniprot.org/uniprot/#_E9PZL8-mappedCitation-31461644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31461644 |
| http://purl.uniprot.org/uniprot/#_P56564-mappedCitation-31461644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31461644 |