| http://purl.uniprot.org/citations/31462647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31462647 | http://www.w3.org/2000/01/rdf-schema#comment | "T cell-mediated autoimmunity encompasses diverse immunopathological outcomes; however, the mechanisms underlying this diversity are largely unknown. Dysfunction of the tripartite linear ubiquitin chain assembly complex (LUBAC) is associated with distinct autonomous immune-related diseases. Cpdm mice lacking Sharpin, an accessory subunit of LUBAC, have innate immune cell-predominant dermatitis triggered by death of LUBAC-compromised keratinocytes. Here we show that specific gene ablation of Sharpin in mouse Treg causes phenotypes mimicking cpdm-like inflammation. Mechanistic analyses find that multiple types of programmed cell death triggered by TNF from tissue-oriented T cells initiate proinflammatory responses to implicate innate immune-mediated pathogenesis in this T cell-mediated inflammation. Moreover, additional disruption of the Hoip locus encoding the catalytic subunit of LUBAC converts cpdm-like dermatitis to T cell-predominant autoimmune lesions; however, innate immune-mediated pathogenesis still remains. These findings show that T cell-mediated killing and sequential autoinflammation are common and crucial for pathogenic diversity during T cell-mediated autoimmune responses."xsd:string |
| http://purl.uniprot.org/citations/31462647 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-11858-7"xsd:string |
| http://purl.uniprot.org/citations/31462647 | http://purl.uniprot.org/core/author | "Nakagawa T."xsd:string |
| http://purl.uniprot.org/citations/31462647 | http://purl.uniprot.org/core/author | "Sasaki Y."xsd:string |
| http://purl.uniprot.org/citations/31462647 | http://purl.uniprot.org/core/author | "Iwai K."xsd:string |
| http://purl.uniprot.org/citations/31462647 | http://purl.uniprot.org/core/author | "Sasaki K."xsd:string |
| http://purl.uniprot.org/citations/31462647 | http://purl.uniprot.org/core/author | "Himeno A."xsd:string |
| http://purl.uniprot.org/citations/31462647 | http://purl.uniprot.org/core/author | "Kiyonari H."xsd:string |
| http://purl.uniprot.org/citations/31462647 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31462647 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/31462647 | http://purl.uniprot.org/core/pages | "3878"xsd:string |
| http://purl.uniprot.org/citations/31462647 | http://purl.uniprot.org/core/title | "Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death."xsd:string |
| http://purl.uniprot.org/citations/31462647 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/31462647 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31462647 |
| http://purl.uniprot.org/citations/31462647 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31462647 |
| http://purl.uniprot.org/uniprot/#_E0CZH2-mappedCitation-31462647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31462647 |
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| http://purl.uniprot.org/uniprot/#_A0A2I3BPT3-mappedCitation-31462647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31462647 |
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