| http://purl.uniprot.org/citations/31465746 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31465746 | http://www.w3.org/2000/01/rdf-schema#comment | "The expressions of LL-37 and KLK-5 were found to be altered in various dermatoses, including atopic dermatitis, psoriasis, and rosacea. However, the downstream inflammatory effect of LL-37 and KLK-5 is not as well studied. In addition, there is little high-quality evidence for the treatment of LL-37- and KLK-5-mediated inflammation. In this study, we investigated the effect of superoxide dismutase 3 (SOD3) on LL-37- or KLK-5-induced skin inflammation in vitro and in vivo and its underlying anti-inflammatory mechanisms. Our data showed that SOD3 significantly reduced both LL-37- and KLK-5-induced expression of pro-inflammatory mediators and suppressed the activation of EGFR, protease-activated receptor 2, nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3, and p38/extracellular signal-regulated kinase signaling pathways in human keratinocytes. Moreover, SOD3 suppressed LL-37-induced expression of inflammatory mediators, reactive oxygen species production, and p38/extracellular signal-regulated kinase activation in mast cells. In addition, subcutaneous injection of KLK-5 in SOD3 knockout mice exhibited erythema with increased epidermal thickness, mast cell and neutrophil infiltration, expression of inflammatory mediators, and activation of EGFR, protease-activated receptor 2, nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3, and downstream mitogen-activated protein kinase pathways. However, treatment with SOD3 in SOD3 knockout mice rescued KLK-5-induced inflammatory cascades. Similarly, KLK-5-induced inflammation in wild-type mice was also ameliorated when treated with SOD3. Taken together, our data suggest that SOD3 is a potentially effective therapy for both LL-37-and KLK-5-induced skin inflammation."xsd:string |
| http://purl.uniprot.org/citations/31465746 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jid.2019.08.434"xsd:string |
| http://purl.uniprot.org/citations/31465746 | http://purl.uniprot.org/core/author | "Choi S.S."xsd:string |
| http://purl.uniprot.org/citations/31465746 | http://purl.uniprot.org/core/author | "Kim T.Y."xsd:string |
| http://purl.uniprot.org/citations/31465746 | http://purl.uniprot.org/core/author | "Nguyen C.T."xsd:string |
| http://purl.uniprot.org/citations/31465746 | http://purl.uniprot.org/core/author | "Kim H.Y."xsd:string |
| http://purl.uniprot.org/citations/31465746 | http://purl.uniprot.org/core/author | "Agrahari G."xsd:string |
| http://purl.uniprot.org/citations/31465746 | http://purl.uniprot.org/core/author | "Sah S.K."xsd:string |
| http://purl.uniprot.org/citations/31465746 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31465746 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/31465746 | http://purl.uniprot.org/core/pages | "656-665.e8"xsd:string |
| http://purl.uniprot.org/citations/31465746 | http://purl.uniprot.org/core/title | "Superoxide Dismutase 3 Inhibits LL-37/KLK-5-Mediated Skin Inflammation through Modulation of EGFR and Associated Inflammatory Cascades."xsd:string |
| http://purl.uniprot.org/citations/31465746 | http://purl.uniprot.org/core/volume | "140"xsd:string |
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