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| http://purl.uniprot.org/citations/31472961 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously reported that the melanocortin-1 receptor (MC1R), a key regulator of melanogenesis, regulates cell migration; however, the detailed mechanism remained unknown. Since the homo-dimerization of MC1R by four inter-subunit disulfide bonds is known to be functionally important for melanogenesis, we investigated the importance of MC1R dimerization for cell migration. Unlike the wild-type MC1R, the dimerization-defective mutant MC1R in which four critical Cys residues were replaced with Ala residues (Cys35-267-273-275Ala) significantly inhibited melanin synthesis but enhanced cell migration in human MNT-1 and A375 melanoma cells. This suggests that there may be a reverse correlation between melanin synthesis and cell migration. Interestingly, melanoma cells expressing the dimerization-defective mutant exhibited enhanced expression of the cell surface heparan sulfate proteoglycan, syndecan-2, and knockdown of syndecan-2 expression decreased the mutant-mediated cell migration. Consistently, ASIP, an antagonist of MC1R, enhanced syndecan-2 expression and cell migration and reversed the α-melanocyte-stimulating hormone (α-MSH)-mediated inhibition of syndecan-2 expression. Furthermore, α-MSH reduced the cell migration of MNT1 cells expressing wild-type MC1R but not its dimerization-defective mutant. Together, these data strongly suggest that MC1R reversely regulates melanin synthesis and migration via the conformational changes induced by dimerization."xsd:string |
| http://purl.uniprot.org/citations/31472961 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2019.08.123"xsd:string |
| http://purl.uniprot.org/citations/31472961 | http://purl.uniprot.org/core/author | "Park J."xsd:string |
| http://purl.uniprot.org/citations/31472961 | http://purl.uniprot.org/core/author | "Jeong D."xsd:string |
| http://purl.uniprot.org/citations/31472961 | http://purl.uniprot.org/core/author | "Jang B."xsd:string |
| http://purl.uniprot.org/citations/31472961 | http://purl.uniprot.org/core/author | "Oh E.S."xsd:string |
| http://purl.uniprot.org/citations/31472961 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31472961 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/31472961 | http://purl.uniprot.org/core/pages | "739-745"xsd:string |
| http://purl.uniprot.org/citations/31472961 | http://purl.uniprot.org/core/title | "The melanocortin-1 receptor reversely regulates the melanin synthesis and migration of melanoma cells via dimerization-induced conformational changes."xsd:string |
| http://purl.uniprot.org/citations/31472961 | http://purl.uniprot.org/core/volume | "518"xsd:string |
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