| http://purl.uniprot.org/citations/31474569 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31474569 | http://www.w3.org/2000/01/rdf-schema#comment | "Progenitor heterogeneity and identities underlying tumor initiation and relapse in medulloblastomas remain elusive. Utilizing single-cell transcriptomic analysis, we demonstrated a developmental hierarchy of progenitor pools in Sonic Hedgehog (SHH) medulloblastomas, and identified OLIG2-expressing glial progenitors as transit-amplifying cells at the tumorigenic onset. Although OLIG2+ progenitors become quiescent stem-like cells in full-blown tumors, they are highly enriched in therapy-resistant and recurrent medulloblastomas. Depletion of mitotic Olig2+ progenitors or Olig2 ablation impeded tumor initiation. Genomic profiling revealed that OLIG2 modulates chromatin landscapes and activates oncogenic networks including HIPPO-YAP/TAZ and AURORA-A/MYCN pathways. Co-targeting these oncogenic pathways induced tumor growth arrest. Together, our results indicate that glial lineage-associated OLIG2+ progenitors are tumor-initiating cells during medulloblastoma tumorigenesis and relapse, suggesting OLIG2-driven oncogenic networks as potential therapeutic targets."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccell.2019.07.009"xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Luo Z."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Smith S.M."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Zhang F."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Zheng T."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Zhou W."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Olson J.M."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Tian W."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Jones B.V."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Drissi R."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Weiss W.A."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Morrissy A.S."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Pomeroy S.L."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Taylor M.D."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Roussel M.F."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Girard E.J."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Xin M."xsd:string |
| http://purl.uniprot.org/citations/31474569 | http://purl.uniprot.org/core/author | "Berry K.P."xsd:string |