| http://purl.uniprot.org/citations/31479733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31479733 | http://www.w3.org/2000/01/rdf-schema#comment | "Although SREBP-1c regulates key enzymes required for hepatic de novo lipogenesis, the mechanisms underlying transcriptional regulation of SREBP-1c in pathogenesis of alcoholic fatty liver is still incompletely understood. In this study, we investigated the role of ERRγ in alcohol-mediated hepatic lipogenesis and examined the possibility to ameliorate alcoholic fatty liver through its inverse agonist. Hepatic ERRγ and SREBP-1c expression was increased by alcohol-mediated activation of CB1 receptor signaling. Deletion and mutation analyses of the Srebp-1c gene promoter showed that ERRγ directly regulates Srebp-1c gene transcription via binding to an ERR-response element. Overexpression of ERRγ significantly induced SREBP-1c expression and fat accumulation in liver of mice, which were blocked in Srebp-1c-knockout hepatocytes. Conversely, liver-specific ablation of ERRγ gene expression attenuated alcohol-mediated induction of SREBP-1c expression. Finally, an ERRγ inverse agonist, GSK5182, significantly ameliorates fatty liver disease in chronically alcohol-fed mice through inhibition of SREBP-1c-mediated fat accumulation. ERRγ mediates alcohol-induced hepatic lipogenesis by upregulating SREBP-1c expression, which can be blunted by the inverse agonist for ERRγ, which may be an attractive therapeutic strategy for the treatment of alcoholic fatty liver disease in human."xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbalip.2019.158521"xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/author | "Kim Y.H."xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/author | "Lee I.K."xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/author | "Kim D.K."xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/author | "Lee C.H."xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/author | "Cho S.J."xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/author | "Choi H.S."xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/author | "Feng R."xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/author | "Jung Y.S."xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/author | "Osborne T.F."xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/author | "Dooley S."xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/author | "Jeon T.I."xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/author | "Im S.S."xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta Mol Cell Biol Lipids"xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/pages | "158521"xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/title | "Estrogen-related receptor gamma controls sterol regulatory element-binding protein-1c expression and alcoholic fatty liver."xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://purl.uniprot.org/core/volume | "1864"xsd:string |
| http://purl.uniprot.org/citations/31479733 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31479733 |
| http://purl.uniprot.org/citations/31479733 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31479733 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQK3-mappedCitation-31479733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31479733 |