| http://purl.uniprot.org/citations/31481213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31481213 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphatidic acid (PA) is a lipid secondary messenger involved in intracellular signaling in eukaryotes. It has been confirmed that PA mediates salt stress signaling by promoting activation of Mitogen-activated Protein Kinase 6 (MPK6) which phosphorylates Na+/H+ antiporter SOS1. However, the MPK6-upstream kinases and their relationship to PA remain unclear. Here, we found that, among the six tested Arabidopsis Mitogen-activated Protein Kinase Kinases (MKKs), PA specifically bound to MKK7 and MKK9 which phosphorylate MPK6, and promoted the activation of MKK7/MKK9. Based on phenotypic and physiological analyses, we found that MKK7 and MKK9 positively regulate Arabidopsis salt tolerance and are functionally redundant. NaCl treatment can induce significant increase in MKK7/MKK9 activities, and this depends, in part, on the Phospholipase Dα1 (PLDα1). MKK7 and MKK9 also mediate the NaCl-induced activation of MPK6. Furthermore, PA or NaCl treatment could induce translocation of MKK7/MKK9 to the plasma membrane, whereas this translocation disappeared in pldα1. These results indicate that PA binds to MKK7 and MKK9, increases their kinase activity and plasma membrane localization during Arabidopsis response to salt stress. Together with the PA-MPK6-SOS1 pathway identified previously, this mechanism may maximize the signal transduction efficiency, providing novel insights into the link between lipid signaling and MAPK cascade."xsd:string |
| http://purl.uniprot.org/citations/31481213 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.plantsci.2019.110190"xsd:string |
| http://purl.uniprot.org/citations/31481213 | http://purl.uniprot.org/core/author | "Shen L."xsd:string |
| http://purl.uniprot.org/citations/31481213 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/31481213 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/31481213 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/31481213 | http://purl.uniprot.org/core/author | "Wu Q."xsd:string |
| http://purl.uniprot.org/citations/31481213 | http://purl.uniprot.org/core/author | "Nie J."xsd:string |
| http://purl.uniprot.org/citations/31481213 | http://purl.uniprot.org/core/author | "Jing W."xsd:string |
| http://purl.uniprot.org/citations/31481213 | http://purl.uniprot.org/core/author | "Zhuang B."xsd:string |
| http://purl.uniprot.org/citations/31481213 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31481213 | http://purl.uniprot.org/core/name | "Plant Sci"xsd:string |
| http://purl.uniprot.org/citations/31481213 | http://purl.uniprot.org/core/pages | "110190"xsd:string |
| http://purl.uniprot.org/citations/31481213 | http://purl.uniprot.org/core/title | "Phosphatidic acid promotes the activation and plasma membrane localization of MKK7 and MKK9 in response to salt stress."xsd:string |
| http://purl.uniprot.org/citations/31481213 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/31481213 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31481213 |
| http://purl.uniprot.org/citations/31481213 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31481213 |
| http://purl.uniprot.org/uniprot/#_A0A178W135-mappedCitation-31481213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31481213 |
| http://purl.uniprot.org/uniprot/#_A0A178W604-mappedCitation-31481213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31481213 |
| http://purl.uniprot.org/uniprot/#_Q39026-mappedCitation-31481213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31481213 |
| http://purl.uniprot.org/uniprot/#_Q38882-mappedCitation-31481213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31481213 |
| http://purl.uniprot.org/uniprot/#_M5BF34-mappedCitation-31481213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31481213 |
| http://purl.uniprot.org/uniprot/#_Q84WM2-mappedCitation-31481213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31481213 |
| http://purl.uniprot.org/uniprot/#_Q9LPQ3-mappedCitation-31481213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31481213 |