| http://purl.uniprot.org/citations/31483837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31483837 | http://www.w3.org/2000/01/rdf-schema#comment | "This study aimed to investigate the expression of sphingosine kinase 1 (SphK-1) and sphingosine 1-phosphate receptor 3 (S1PR-3) in a mouse model of malaria-associated acute lung injury/acute respiratory distress syndrome (ALI/ARDS). DBA/2 mice were infected with Plasmodium berghei ANKA to generate an experimental model of malaria-associated ALI/ARDS. The infected mice were divided into 2 groups based on the histopathological study of lung tissues: those with and those without ALI/ARDS. The expression of the SphK-1 and S1PR-3 proteins in the lung tissues was investigated using immunohistochemical staining and Western blot analysis. In addition, the S1P level was quantified in plasma and lung tissues using an enzyme-linked immunosorbent assay (ELISA). The results demonstrated that the cellular expression of the SphK-1 and S1PR-3 proteins was significantly upregulated in endothelial cells, alveolar epithelial cells and alveolar macrophages in the lung tissues of malaria-infected mice with ALI/ARDS compared with those in the control groups. The increased expression of the SphK-1 and S1PR-3 proteins was confirmed using Western blot analysis. The concentration of S1P in plasma and lung tissues was significantly decreased in malaria-infected mice with ALI/ARDS compared with non-ALI/ARDS and control mice. Furthermore, increased expression of the SphK-1 and S1PR-3 proteins significantly correlated with lung injury scores and S1P concentrations in malaria-infected mice with ALI/ARDS. These findings highlight increased expression of SphK-1 and S1PR-3 in the lung tissues of malaria-infected mice with ALI/ARDS."xsd:string |
| http://purl.uniprot.org/citations/31483837 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0222098"xsd:string |
| http://purl.uniprot.org/citations/31483837 | http://purl.uniprot.org/core/author | "Viriyavejakul P."xsd:string |
| http://purl.uniprot.org/citations/31483837 | http://purl.uniprot.org/core/author | "Punsawad C."xsd:string |
| http://purl.uniprot.org/citations/31483837 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31483837 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/31483837 | http://purl.uniprot.org/core/pages | "e0222098"xsd:string |
| http://purl.uniprot.org/citations/31483837 | http://purl.uniprot.org/core/title | "Expression of sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 in malaria-associated acute lung injury/acute respiratory distress syndrome in a mouse model."xsd:string |
| http://purl.uniprot.org/citations/31483837 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/31483837 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31483837 |
| http://purl.uniprot.org/citations/31483837 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31483837 |
| http://purl.uniprot.org/uniprot/#_Q9Z0U9-mappedCitation-31483837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31483837 |
| http://purl.uniprot.org/uniprot/Q9Z0U9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31483837 |