| http://purl.uniprot.org/citations/31484064 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31484064 | http://www.w3.org/2000/01/rdf-schema#comment | "V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA) is an immune checkpoint protein that inhibits the T cell response against cancer. Similar to PD-1 and CTLA-4, a blockade of VISTA promotes tumor clearance by the immune system. Here, we report a 1.85 Å crystal structure of the elusive human VISTA extracellular domain, whose lack of homology necessitated a combinatorial MR-Rosetta approach for structure determination. We highlight features that make the VISTA immunoglobulin variable (IgV)-like fold unique among B7 family members, including two additional disulfide bonds and an extended loop region with an attached helix that we show forms a contiguous binding epitope for a clinically relevant anti-VISTA antibody. We propose an overlap of this antibody-binding region with the binding epitope for V-set and Ig domain containing 3 (VSIG3), a purported functional binding partner of VISTA. The structure and functional epitope presented here will help guide future drug development efforts against this important checkpoint target."xsd:string |
| http://purl.uniprot.org/citations/31484064 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2019.07.073"xsd:string |
| http://purl.uniprot.org/citations/31484064 | http://purl.uniprot.org/core/author | "Mathews I.I."xsd:string |
| http://purl.uniprot.org/citations/31484064 | http://purl.uniprot.org/core/author | "Mehta N."xsd:string |
| http://purl.uniprot.org/citations/31484064 | http://purl.uniprot.org/core/author | "Huang P.S."xsd:string |
| http://purl.uniprot.org/citations/31484064 | http://purl.uniprot.org/core/author | "Maddineni S."xsd:string |
| http://purl.uniprot.org/citations/31484064 | http://purl.uniprot.org/core/author | "Cochran J.R."xsd:string |
| http://purl.uniprot.org/citations/31484064 | http://purl.uniprot.org/core/author | "Andres Parra Sperberg R."xsd:string |
| http://purl.uniprot.org/citations/31484064 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31484064 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/31484064 | http://purl.uniprot.org/core/pages | "2509-2516.e5"xsd:string |
| http://purl.uniprot.org/citations/31484064 | http://purl.uniprot.org/core/title | "Structure and Functional Binding Epitope of V-domain Ig Suppressor of T Cell Activation."xsd:string |
| http://purl.uniprot.org/citations/31484064 | http://purl.uniprot.org/core/volume | "28"xsd:string |
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