| http://purl.uniprot.org/citations/31488873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31488873 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently, we detected a new fusion transcript LMO3-BORCS5 in a patient with Ewing sarcoma within a cohort of relapsed pediatric cancers. LMO3-BORCS5 was as highly expressed as the characteristic fusion oncogene EWS/FLI1. However, the expression level of LMO3-BORCS5 at diagnosis was very low. Sanger sequencing depicted two LMO3-BORCS5 variants leading to loss of the functional domain LIM2 in LMO3 gene, and disruption of BORCS5. In vitro studies showed that LMO3-BORCS5 (i) increases proliferation, (ii) decreases expression of apoptosis-related genes and treatment sensitivity, and (iii) downregulates genes involved in differentiation and upregulates proliferative and extracellular matrix-related pathways. Remarkably, in vivo LMO3-BORCS5 demonstrated its high oncogenic potential by inducing tumors in mouse fibroblastic NIH-3T3 cell line. Moreover, BORCS5 probably acts, in vivo, as a tumor-suppressor gene. In conclusion, functional studies of fusion oncogenes at relapse are of great importance to define mechanisms involved in tumor progression and resistance to conventional treatments."xsd:string |
| http://purl.uniprot.org/citations/31488873 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41388-019-0914-3"xsd:string |
| http://purl.uniprot.org/citations/31488873 | http://purl.uniprot.org/core/author | "Massaad-Massade L."xsd:string |
| http://purl.uniprot.org/citations/31488873 | http://purl.uniprot.org/core/author | "Gracia C."xsd:string |
| http://purl.uniprot.org/citations/31488873 | http://purl.uniprot.org/core/author | "Riviere J."xsd:string |
| http://purl.uniprot.org/citations/31488873 | http://purl.uniprot.org/core/author | "Geoerger B."xsd:string |
| http://purl.uniprot.org/citations/31488873 | http://purl.uniprot.org/core/author | "Dupain C."xsd:string |
| http://purl.uniprot.org/citations/31488873 | http://purl.uniprot.org/core/author | "Harttrampf A.C."xsd:string |
| http://purl.uniprot.org/citations/31488873 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31488873 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/31488873 | http://purl.uniprot.org/core/pages | "7200-7215"xsd:string |
| http://purl.uniprot.org/citations/31488873 | http://purl.uniprot.org/core/title | "Newly identified LMO3-BORCS5 fusion oncogene in Ewing sarcoma at relapse is a driver of tumor progression."xsd:string |
| http://purl.uniprot.org/citations/31488873 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/31488873 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31488873 |
| http://purl.uniprot.org/citations/31488873 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31488873 |
| http://purl.uniprot.org/uniprot/#_B4DGL5-mappedCitation-31488873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31488873 |
| http://purl.uniprot.org/uniprot/#_B2R631-mappedCitation-31488873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31488873 |
| http://purl.uniprot.org/uniprot/#_G3V1P3-mappedCitation-31488873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31488873 |
| http://purl.uniprot.org/uniprot/#_Q05D86-mappedCitation-31488873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31488873 |
| http://purl.uniprot.org/uniprot/#_Q9NYC6-mappedCitation-31488873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31488873 |
| http://purl.uniprot.org/uniprot/#_Q8TAP4-mappedCitation-31488873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31488873 |
| http://purl.uniprot.org/uniprot/#_Q969J3-mappedCitation-31488873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31488873 |
| http://purl.uniprot.org/uniprot/G3V1P3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31488873 |
| http://purl.uniprot.org/uniprot/B4DGL5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31488873 |