| http://purl.uniprot.org/citations/31491385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31491385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31491385 | http://www.w3.org/2000/01/rdf-schema#comment | "Prion-like proteins can assume distinct conformational and physical states in the same cell. Sequence analysis suggests that prion-like proteins are prevalent in various species; however, it remains unclear what functional space they occupy in multicellular organisms. Here, we report the identification of a prion-like protein, Herzog (CG5830), through a multimodal screen in Drosophila melanogaster. Herzog functions as a membrane-associated phosphatase and controls embryonic patterning, likely being involved in TGF-β/BMP and FGF/EGF signaling pathways. Remarkably, monomeric Herzog is enzymatically inactive and becomes active upon amyloid-like assembly. The prion-like domain of Herzog is necessary for both its assembly and membrane targeting. Removal of the prion-like domain impairs activity, while restoring assembly on the membrane using a heterologous prion-like domain and membrane-targeting motif can restore phosphatase activity. This study provides an example of a prion-like domain that allows an enzyme to gain essential functionality via amyloid-like assembly to control animal development."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2019.08.019"xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2019.08.019"xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Yu Z."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Yu Z."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Saraf A."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Saraf A."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Yi K."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Yi K."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Si K."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Si K."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Leal P."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Leal P."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Lange J.J."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Lange J.J."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Nil Z."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Nil Z."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Gerbich T."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Gerbich T."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Hervas R."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Hervas R."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Sardiu M."xsd:string |
| http://purl.uniprot.org/citations/31491385 | http://purl.uniprot.org/core/author | "Sardiu M."xsd:string |