| http://purl.uniprot.org/citations/31491533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31491533 | http://www.w3.org/2000/01/rdf-schema#comment | "Reelin plays important roles in regulating neuronal development, modulating synaptic function, and counteracting amyloid β toxicity. A specific proteolytic cleavage (N-t cleavage) of Reelin abolishes its biological activity. We recently identified ADAMTS-3 (a disintegrin and metalloproteinase with thrombospondin motifs 3) as the major N-t cleavage enzyme in the embryonic and early postnatal brain. The contribution of other proteases, particularly in the postnatal brain, has not been demonstrated in vivo. ADAMTS-2, -3 and -14 share similar domain structures and substrate specificity, raising the possibility that ADAMTS-2 and -14 may cleave Reelin. We found that recombinant ADAMTS-2 protein expressed in cultured cell lines cleaves Reelin at the N-t site as efficiently as ADAMTS-3 while recombinant ADAMTS-14 hardly cleaves Reelin. The disintegrin domain is necessary for the Reelin-cleaving activity of ADAMTS-2 and -3. ADAMTS-2 is expressed in the adult brain at approximately the same level as ADAMTS-3. We generated ADAMTS-2 knockout (KO) mice and found that ADAMTS-2 significantly contributes to the N-t cleavage and inactivation of Reelin in the postnatal cerebral cortex and hippocampus, but much less in the cerebellum. Therefore, it was suggested that ADAMTS-2 can be a therapeutic target for adult brain disorders such as schizophrenia and Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/31491533 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mcn.2019.103401"xsd:string |
| http://purl.uniprot.org/citations/31491533 | http://purl.uniprot.org/core/author | "Hattori M."xsd:string |
| http://purl.uniprot.org/citations/31491533 | http://purl.uniprot.org/core/author | "Ishii K."xsd:string |
| http://purl.uniprot.org/citations/31491533 | http://purl.uniprot.org/core/author | "Miyamoto T."xsd:string |
| http://purl.uniprot.org/citations/31491533 | http://purl.uniprot.org/core/author | "Kato M."xsd:string |
| http://purl.uniprot.org/citations/31491533 | http://purl.uniprot.org/core/author | "Ogino H."xsd:string |
| http://purl.uniprot.org/citations/31491533 | http://purl.uniprot.org/core/author | "Kohno T."xsd:string |
| http://purl.uniprot.org/citations/31491533 | http://purl.uniprot.org/core/author | "Kamei T."xsd:string |
| http://purl.uniprot.org/citations/31491533 | http://purl.uniprot.org/core/author | "Ishizuka T."xsd:string |
| http://purl.uniprot.org/citations/31491533 | http://purl.uniprot.org/core/author | "Oishi H."xsd:string |
| http://purl.uniprot.org/citations/31491533 | http://purl.uniprot.org/core/author | "Tsuiji H."xsd:string |
| http://purl.uniprot.org/citations/31491533 | http://purl.uniprot.org/core/author | "Hongo A."xsd:string |
| http://purl.uniprot.org/citations/31491533 | http://purl.uniprot.org/core/author | "Yamakage Y."xsd:string |
| http://purl.uniprot.org/citations/31491533 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31491533 | http://purl.uniprot.org/core/name | "Mol Cell Neurosci"xsd:string |
| http://purl.uniprot.org/citations/31491533 | http://purl.uniprot.org/core/pages | "103401"xsd:string |
| http://purl.uniprot.org/citations/31491533 | http://purl.uniprot.org/core/title | "A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum."xsd:string |
| http://purl.uniprot.org/citations/31491533 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/31491533 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31491533 |
| http://purl.uniprot.org/citations/31491533 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31491533 |
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| http://purl.uniprot.org/uniprot/#_A0A0N4SVN2-mappedCitation-31491533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31491533 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1E1-mappedCitation-31491533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31491533 |