| http://purl.uniprot.org/citations/31492908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31492908 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor 7-like 2 (TCF7L2) polymorphism rs7903146 is known to be tightly associated with an elevated risk for type 2 diabetes, whereas the molecular mechanisms remain elusive. We evaluated the metabolic profile of a total of 394 patients' serum samples with respect to their rs7903146 genotype using targeted metabolomics in a discovery (n = 154) and a validation (n = 240) study. We have identified serotonin as the top metabolite being increased in carriers of the risk allele. Serotonin was significantly associated with the rs7903146 genotype after full adjustment including type 2 diabetes and further top ranked metabolites. Given the role of peripheral serotonin in metabolic homeostasis and type 2 diabetes, this finding provides a first hint that the well-known impact of the TCF7L2 polymorphism on type 2 diabetes risk may involve a serotonin-dependent pathway."xsd:string |
| http://purl.uniprot.org/citations/31492908 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-019-49347-y"xsd:string |
| http://purl.uniprot.org/citations/31492908 | http://purl.uniprot.org/core/author | "Muendlein A."xsd:string |
| http://purl.uniprot.org/citations/31492908 | http://purl.uniprot.org/core/author | "Leiherer A."xsd:string |
| http://purl.uniprot.org/citations/31492908 | http://purl.uniprot.org/core/author | "Fraunberger P."xsd:string |
| http://purl.uniprot.org/citations/31492908 | http://purl.uniprot.org/core/author | "Drexel H."xsd:string |
| http://purl.uniprot.org/citations/31492908 | http://purl.uniprot.org/core/author | "Saely C.H."xsd:string |
| http://purl.uniprot.org/citations/31492908 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31492908 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/31492908 | http://purl.uniprot.org/core/pages | "12863"xsd:string |
| http://purl.uniprot.org/citations/31492908 | http://purl.uniprot.org/core/title | "Serotonin is elevated in risk-genotype carriers of TCF7L2 - rs7903146."xsd:string |
| http://purl.uniprot.org/citations/31492908 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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