| http://purl.uniprot.org/citations/31493975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31493975 | http://www.w3.org/2000/01/rdf-schema#comment | "More than 8,000 genes are turned on or off as progenitor cells produce the 7 classes of retinal cell types during development. Thousands of enhancers are also active in the developing retinae, many having features of cell- and developmental stage-specific activity. We studied dynamic changes in the 3D chromatin landscape important for precisely orchestrated changes in gene expression during retinal development by ultra-deep in situ Hi-C analysis on murine retinae. We identified developmental-stage-specific changes in chromatin compartments and enhancer-promoter interactions. We developed a machine learning-based algorithm to map euchromatin and heterochromatin domains genome-wide and overlaid it with chromatin compartments identified by Hi-C. Single-cell ATAC-seq and RNA-seq were integrated with our Hi-C and previous ChIP-seq data to identify cell- and developmental-stage-specific super-enhancers (SEs). We identified a bipolar neuron-specific core regulatory circuit SE upstream of Vsx2, whose deletion in mice led to the loss of bipolar neurons."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2019.08.002"xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/author | "Johnson D."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/author | "Zhou X."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/author | "Shao Y."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/author | "Xu B."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/author | "Miller S."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/author | "Frase S."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/author | "Dyer M.A."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/author | "Stewart V."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/author | "Valentine M."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/author | "Easton J."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/author | "Griffiths L."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/author | "Norrie J.L."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/author | "Al Diri I."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/author | "Honnell V."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/author | "Lupo M.S."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/author | "Putnam D."xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/pages | "512-528.e11"xsd:string |
| http://purl.uniprot.org/citations/31493975 | http://purl.uniprot.org/core/title | "Nucleome Dynamics during Retinal Development."xsd:string |