| http://purl.uniprot.org/citations/31501481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31501481 | http://www.w3.org/2000/01/rdf-schema#comment | "TRAF3 is a versatile intracellular adapter protein with multiple context-specific roles. Uniquely in B cells, TRAF3 deficiency enhances survival and increases the risk of transformation, as loss of TRAF3 is observed in several types of B cell cancers. Here, we report a new mechanism for TRAF3 in the restraint of B cell survival. We found that TRAF3 deficiency was associated with induction of the pro-survival kinase Pim2 in mouse primary B cells and human malignant B cell lines. The increase in Pim2 was independent of NF-κB2 activation but was ameliorated with inhibition of STAT3 expression or function. TRAF3 deficiency also led to a Pim2-dependent increase in c-Myc protein levels and was associated with reduced c-Myc ubiquitination. TRAF3-deficient primary B cells were less sensitive to cell death induced by the Pim inhibitors SGI-1776 and TP-3654. Interestingly, human malignant B cell lines with low expression of TRAF3 were more sensitive to Pim inhibition-induced cell death. Combination treatment of TRAF3-deficient B cells and B cell tumor lines with c-Myc inhibitors enhanced their sensitivity to Pim inhibition, suggesting a possible therapeutic strategy. TRAF3 thus suppresses a Pim2-mediated B cell survival axis, which can be a potential target for treatment of B cell malignancies."xsd:string |
| http://purl.uniprot.org/citations/31501481 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-019-49390-9"xsd:string |
| http://purl.uniprot.org/citations/31501481 | http://purl.uniprot.org/core/author | "Bishop G.A."xsd:string |
| http://purl.uniprot.org/citations/31501481 | http://purl.uniprot.org/core/author | "Lin W.W."xsd:string |
| http://purl.uniprot.org/citations/31501481 | http://purl.uniprot.org/core/author | "Stunz L.L."xsd:string |
| http://purl.uniprot.org/citations/31501481 | http://purl.uniprot.org/core/author | "Mambetsariev N."xsd:string |
| http://purl.uniprot.org/citations/31501481 | http://purl.uniprot.org/core/author | "Whillock A.L."xsd:string |
| http://purl.uniprot.org/citations/31501481 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31501481 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/31501481 | http://purl.uniprot.org/core/pages | "12884"xsd:string |
| http://purl.uniprot.org/citations/31501481 | http://purl.uniprot.org/core/title | "TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells."xsd:string |
| http://purl.uniprot.org/citations/31501481 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/31501481 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31501481 |
| http://purl.uniprot.org/citations/31501481 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31501481 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-31501481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31501481 |
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| http://purl.uniprot.org/uniprot/#_B3CJB3-mappedCitation-31501481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31501481 |
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