Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/31504696http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31504696http://www.w3.org/2000/01/rdf-schema#comment"

Background

Transcription factor 7-like 2 (TCF7L2) genetic variants that predispose individuals to type 2 diabetes (T2D) show inconsistent associations with anthropometric traits. Interaction between TCF7L2 genotypes and dietary factors may help explain these observations.

Objective

We aimed to examine the potential modulation of TCF7L2-rs7903146 and rs12255372 on anthropometric markers by a Mediterranean diet (MedDiet).

Methods

Cross-sectional analysis was conducted in 1120 participants (aged 45-75 y) of the Boston Puerto Rican Health Study. Anthropometric variables were measured, and polymorphisms were genotyped using standardized protocols. Diet was assessed using a validated FFQ. The MedDiet was defined based on adherence to 9 food and nutrient components using sex-specific population-based median cut-offs; high adherence was defined as meeting ≥4 components. Haplotypes were tested for association with obesity traits, independently and via interaction with the MedDiet.

Results

TCF7L2-rs7903146 showed significant interaction with the MedDiet influencing BMI, weight, and waist circumference. The T risk-allele carriers (CT + TT) with a high MedDiet score had lower weight (77.3 ± 1.0 compared with CC 80.9 ± 1.0 kg; P = 0.013) and waist circumference (99.2 ± 0.9 compared with CC 102.2 ± 0.9 cm; P = 0.021), when compared with CC participants. A low MedDiet score resulted in no significant differences between genotypes. For TCF7L2-rs12255372, we found significant interactions with the MedDiet for weight (P-interaction = 0.034) and BMI (P-interaction = 0.036). The T allele carriers with a higher MedDiet score showed a trend of lower but no significant differences when compared with CC participants for BMI (P = 0.19), weight (P = 0.09), and waist circumference (P = 0.11). We found significant interactions between the 2 risk-carrying haplotypes and the MedDiet compared with the common haplotype (GC), with lower BMI (β ± SE, TT: -1.53 ± 0.68; P-interaction = 0.024), weight (TT: -4.16 ± 1.77; P-interaction = 0.019), and waist circumference (GT: -5.07 ± 2.50; P-interaction = 0.042) at a high MedDiet score.

Conclusion

Puerto Ricans with the TCF7L2-rs7903146 and rs12255372 T2D risk genotypes, although still high, had better anthropometric profiles when adhering to a MedDiet, suggesting that this diet may offset unfavorable genetic predisposition."xsd:string
http://purl.uniprot.org/citations/31504696http://purl.org/dc/terms/identifier"doi:10.1093/jn/nxz210"xsd:string
http://purl.uniprot.org/citations/31504696http://purl.uniprot.org/core/author"Smith C.E."xsd:string
http://purl.uniprot.org/citations/31504696http://purl.uniprot.org/core/author"Ordovas J.M."xsd:string
http://purl.uniprot.org/citations/31504696http://purl.uniprot.org/core/author"Tucker K.L."xsd:string
http://purl.uniprot.org/citations/31504696http://purl.uniprot.org/core/author"Lai C.Q."xsd:string
http://purl.uniprot.org/citations/31504696http://purl.uniprot.org/core/author"Mattei J."xsd:string
http://purl.uniprot.org/citations/31504696http://purl.uniprot.org/core/author"Sotos-Prieto M."xsd:string
http://purl.uniprot.org/citations/31504696http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/31504696http://purl.uniprot.org/core/name"J Nutr"xsd:string
http://purl.uniprot.org/citations/31504696http://purl.uniprot.org/core/pages"167-175"xsd:string
http://purl.uniprot.org/citations/31504696http://purl.uniprot.org/core/title"Mediterranean Diet Adherence Modulates Anthropometric Measures by TCF7L2 Genotypes among Puerto Rican Adults."xsd:string
http://purl.uniprot.org/citations/31504696http://purl.uniprot.org/core/volume"150"xsd:string
http://purl.uniprot.org/citations/31504696http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/31504696
http://purl.uniprot.org/citations/31504696http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/31504696
http://purl.uniprot.org/uniprot/#_A0A0D9SGH8-mappedCitation-31504696http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31504696
http://purl.uniprot.org/uniprot/#_A0A0A0MTL7-mappedCitation-31504696http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31504696
http://purl.uniprot.org/uniprot/#_E2GH26-mappedCitation-31504696http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31504696
http://purl.uniprot.org/uniprot/#_A0A994J711-mappedCitation-31504696http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31504696
http://purl.uniprot.org/uniprot/#_A0A2Z5HTM8-mappedCitation-31504696http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31504696
http://purl.uniprot.org/uniprot/#_A0A2Z5HTN9-mappedCitation-31504696http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31504696
http://purl.uniprot.org/uniprot/#_B4DJZ2-mappedCitation-31504696http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31504696
http://purl.uniprot.org/uniprot/#_B3KQC6-mappedCitation-31504696http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31504696
http://purl.uniprot.org/uniprot/#_B4DWD5-mappedCitation-31504696http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31504696
▶