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http://purl.uniprot.org/citations/31505435http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objective

The aim of this work was to evaluate a pediatric ependymoma protein expression that may be useful as a molecular biomarker candidate for prognosis, correlated with clinical features such as age, gender, histopathological grade, ependymal tumor recurrence and patient survival.

Patients and methods

Immunohistochemistry assays were performed for GNAO1, ASAH1, IMMT, IPO7, Cyclin D1, P53 and Ki-67 proteins. Kaplan-Meier and Cox analysis were performed for age, gender, histopathological grade, relapse and survival correlation.

Results

We found that three proteins correlate with histopathological grade and relapse; two proteins correlate with survival; one protein does not correlate with any clinical feature.

Conclusion

Our results suggest that, out of the proteins analyzed, five may be considered suitable prognostic biomarkers and one may be considered a predictive biomarker for response to treatment of pediatric ependymoma."xsd:string
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http://purl.uniprot.org/citations/31505435http://purl.uniprot.org/core/author"Gomez C."xsd:string
http://purl.uniprot.org/citations/31505435http://purl.uniprot.org/core/author"Garcia-Mendez A."xsd:string
http://purl.uniprot.org/citations/31505435http://purl.uniprot.org/core/author"Chavarria A."xsd:string
http://purl.uniprot.org/citations/31505435http://purl.uniprot.org/core/author"Garcia-Hernandez N."xsd:string
http://purl.uniprot.org/citations/31505435http://purl.uniprot.org/core/author"Perez-Ramirez M."xsd:string
http://purl.uniprot.org/citations/31505435http://purl.uniprot.org/core/author"Siordia-Reyes A.G."xsd:string
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http://purl.uniprot.org/citations/31505435http://purl.uniprot.org/core/name"Clin Neurol Neurosurg"xsd:string
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http://purl.uniprot.org/citations/31505435http://purl.uniprot.org/core/title"Pediatric ependymoma: GNAO1, ASAH1, IMMT and IPO7 protein expression and 5-year prognosis correlation."xsd:string
http://purl.uniprot.org/citations/31505435http://purl.uniprot.org/core/volume"186"xsd:string
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