| http://purl.uniprot.org/citations/31511356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31511356 | http://www.w3.org/2000/01/rdf-schema#comment | "House dust mite (HDM) extract is a common trigger of asthma in humans. Chronic exposure to HDM also induces asthma-like pathology in mice. Allergic responses to HDM and other allergens are linked to release of IL-25, IL-33, and TSLP by epithelial cells; these cytokines, especially IL-33, target innate lymphoid cells type 2 to produce type 2 cytokines. To what extent and by what mechanisms IL-25 contributes to chronic HDM-induced pathology is not well understood. In humans, elevated levels of IL-25 appear to be associated with cases of uncontrolled asthma and exacerbated attacks. In this article, we demonstrate that blockade of IL-25 signaling in either lung conventional dendritic cells or in T cells resulted in similar decreases in production of IL-13 and IL-9 by T cells, reduced mast cell accumulation and tissue remodeling, and improved lung function but had only modest effects on eosinophilia. Stimulation of conventional dendritic cells by IL-25 promoted proximal accumulation of Th cells, and stimulation of Th cells by IL-25 locally promoted IL-13 and IL-9 production. IL-25 made notable contributions to chronic HDM-induced allergic asthma pathology by facilitating clustering and cross-stimulation of different cell types in tissue. Therapeutic targeting of IL-25 in combination with other treatments may be beneficial."xsd:string |
| http://purl.uniprot.org/citations/31511356 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1900254"xsd:string |
| http://purl.uniprot.org/citations/31511356 | http://purl.uniprot.org/core/author | "Tang W."xsd:string |
| http://purl.uniprot.org/citations/31511356 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/31511356 | http://purl.uniprot.org/core/author | "Siebenlist U."xsd:string |
| http://purl.uniprot.org/citations/31511356 | http://purl.uniprot.org/core/author | "Kamenyeva O."xsd:string |
| http://purl.uniprot.org/citations/31511356 | http://purl.uniprot.org/core/author | "Claudio E."xsd:string |
| http://purl.uniprot.org/citations/31511356 | http://purl.uniprot.org/core/author | "Ha H.L."xsd:string |
| http://purl.uniprot.org/citations/31511356 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31511356 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/31511356 | http://purl.uniprot.org/core/pages | "2319-2327"xsd:string |
| http://purl.uniprot.org/citations/31511356 | http://purl.uniprot.org/core/title | "IL-25 Orchestrates Activation of Th Cells via Conventional Dendritic Cells in Tissue to Exacerbate Chronic House Dust Mite-Induced Asthma Pathology."xsd:string |
| http://purl.uniprot.org/citations/31511356 | http://purl.uniprot.org/core/volume | "203"xsd:string |
| http://purl.uniprot.org/citations/31511356 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31511356 |
| http://purl.uniprot.org/citations/31511356 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31511356 |
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