| http://purl.uniprot.org/citations/31511510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31511510 | http://www.w3.org/2000/01/rdf-schema#comment | "Type I interferons (IFN) are being rediscovered as potent anti-tumoral agents. Activation of the STimulator of INterferon Genes (STING) by DMXAA (5,6-dimethylxanthenone-4-acetic acid) can induce strong production of IFNα/β and rejection of transplanted primary tumors. In the present study, we address whether targeting STING with DMXAA also leads to the regression of spontaneous MMTV-PyMT mammary tumors. We show that these tumors are refractory to DMXAA-induced regression. This is due to a blockade in the phosphorylation of IRF3 and the ensuing IFNα/β production. Mechanistically, we identify TGFβ, which is abundant in spontaneous tumors, as a key molecule limiting this IFN-induced tumor regression by DMXAA. Finally, blocking TGFβ restores the production of IFNα by activated MHCII+ tumor-associated macrophages, and enables tumor regression induced by STING activation. On the basis of these findings, we propose that type I IFN-dependent cancer therapies could be greatly improved by combinations including the blockade of TGFβ."xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-11998-w"xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://purl.uniprot.org/core/author | "Altan-Bonnet G."xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://purl.uniprot.org/core/author | "Bismuth G."xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://purl.uniprot.org/core/author | "Regnier F."xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://purl.uniprot.org/core/author | "Weiss J.M."xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://purl.uniprot.org/core/author | "Trautmann A."xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://purl.uniprot.org/core/author | "Donnadieu E."xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://purl.uniprot.org/core/author | "Bercovici N."xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://purl.uniprot.org/core/author | "Feuillet V."xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://purl.uniprot.org/core/author | "Finisguerra V."xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://purl.uniprot.org/core/author | "Vimeux L."xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://purl.uniprot.org/core/author | "Guilbert T."xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://purl.uniprot.org/core/author | "Guerin M.V."xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://purl.uniprot.org/core/author | "Thoreau M."xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31511510 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://purl.uniprot.org/core/pages | "4131"xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://purl.uniprot.org/core/title | "TGFbeta blocks IFNalpha/beta release and tumor rejection in spontaneous mammary tumors."xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/31511510 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31511510 |
| http://purl.uniprot.org/citations/31511510 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31511510 |
| http://purl.uniprot.org/uniprot/#_E9Q6I6-mappedCitation-31511510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31511510 |
| http://purl.uniprot.org/uniprot/#_Q0VE17-mappedCitation-31511510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31511510 |