| http://purl.uniprot.org/citations/31511615 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31511615 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammals have evolved many antiviral factors impacting different steps of the viral life cycle. Associated with chromatin-modifying enzymes, the cellular cofactor CTIP2 contributes to HIV-1 gene silencing in latently infected reservoirs that constitute the major block toward an HIV cure. We report, for the first time, that the virus has developed a strategy to overcome this major transcriptional block. Productive HIV-1 infection results in a Vpr-mediated depletion of CTIP2 in microglial cells and CD4+ T cells, two of the major viral reservoirs. Associated to the Cul4A-DDB1-DCAF1 ubiquitin ligase complex, Vpr promotes CTIP2 degradation via the proteasome pathway in the nuclei of target cells and notably at the latent HIV-1 promoter. Importantly, Vpr targets CTIP2 associated with heterochromatin-promoting enzymes dedicated to HIV-1 gene silencing. Thereby, Vpr reactivates HIV-1 expression in a microglial model of HIV-1 latency. Altogether our results suggest that HIV-1 Vpr mediates the depletion of the cellular repressor CTIP2 to counteract viral gene silencing."xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-019-48689-x"xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/author | "Schwartz C."xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/author | "Ali S."xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/author | "Boutant E."xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/author | "Margottin-Goguet F."xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/author | "Van Lint C."xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/author | "Moog C."xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/author | "Forouzanfar F."xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/author | "Rohr O."xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/author | "Wallet C."xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/author | "El Maassarani M."xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/author | "Ait-Ammar A."xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/author | "Daouad F."xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/author | "De Rovere M."xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/author | "Ducloy C."xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/author | "El Mekdad H."xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/author | "Van Assche J."xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/pages | "13154"xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/title | "HIV-1 Vpr mediates the depletion of the cellular repressor CTIP2 to counteract viral gene silencing."xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/31511615 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31511615 |