http://purl.uniprot.org/citations/31515149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/31515149 | http://www.w3.org/2000/01/rdf-schema#comment | "Background and aimsNo report explored the combined effects of HLA-DPA1 and -DPB1 with long-term response to hepatitis B (HB) vaccination (HBVac). The specific aims of the study were to assess the combined effects and relative contributions of DPA1 and DPB1 genes.MethodsThe cases were 152 adolescents who had undetectable (<1.0 mIU/mL) post-booster anti-HBs titers and the controls were adolescents who had residual anti-HBs ≥ 10 mIU/mL at aged 16 years (n = 207) or had detectable (≥1.0 mIU/mL) anti-HBs titers after booster HBVac (n = 481). HLA-DPA1 and -DPB1 genotypes were determined by sequence-based typing.ResultsHLA-DPA1*01:03:01 was correlated with lower ORs of undetectable anti-HBs titers, while -DPA1*02:02:02 and -DPB1*05:01:01 were correlated with higher ORs. The ORs for HLA-DPA1*01:03:01-DPB1*05:01:01 and DPA1*02:02:02-DPB1*protective combinatory types were significantly less than 1.0. As compared with subjects who had no protective allele, the adjusted ORs (95% CI) were 0.545 (0.328-0.906), 0.350 (0.174-0.702), and 0.122 (0.058-0.257), for subjects who had protective alleles on DPA1only, DPB1 only, and both genes, respectively. Analyses of amino acid polymorphisms showed that subjects who carried Arg81-Pro158-Val191-Pro259α + Met234β and Gln62-Arg82α + Met234β combinations had 4.3-to-4.6 folds of risks.ConclusionBoth DPA1 and DPB1 genes contribute to the persistence of immunological response to primary infantile HBVac. The effects of HLA-DP risk alleles were dominated by the protective alleles and there were significant gene-gene interactions. Our findings provide evidences for the design of more potent HB vaccine."xsd:string |
http://purl.uniprot.org/citations/31515149 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.vaccine.2019.09.001"xsd:string |
http://purl.uniprot.org/citations/31515149 | http://purl.uniprot.org/core/author | "Wang L.Y."xsd:string |
http://purl.uniprot.org/citations/31515149 | http://purl.uniprot.org/core/author | "Lin H.H."xsd:string |
http://purl.uniprot.org/citations/31515149 | http://purl.uniprot.org/core/author | "Lai S.K."xsd:string |
http://purl.uniprot.org/citations/31515149 | http://purl.uniprot.org/core/author | "Chen C.F."xsd:string |
http://purl.uniprot.org/citations/31515149 | http://purl.uniprot.org/core/author | "Chu C.C."xsd:string |
http://purl.uniprot.org/citations/31515149 | http://purl.uniprot.org/core/author | "Wu T.W."xsd:string |
http://purl.uniprot.org/citations/31515149 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
http://purl.uniprot.org/citations/31515149 | http://purl.uniprot.org/core/name | "Vaccine"xsd:string |
http://purl.uniprot.org/citations/31515149 | http://purl.uniprot.org/core/pages | "6435-6440"xsd:string |
http://purl.uniprot.org/citations/31515149 | http://purl.uniprot.org/core/title | "Response to hepatitis B vaccination is co-determined by HLA-DPA1 and -DPB1."xsd:string |
http://purl.uniprot.org/citations/31515149 | http://purl.uniprot.org/core/volume | "37"xsd:string |
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