| http://purl.uniprot.org/citations/31515941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31515941 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-6 (IL-6) is a growth factor for normal B cells and plasma cell-derived malignancies. Here, we show that the IL-6 signaling pathway is also active in a subset of diffuse large B-cell lymphoma (DLBCL) patients with particularly poor prognosis. Primary DLBCL cells and DLBCL cell lines expressing IL-6R engraft and form orthotopic lymphomas in humanized mice that ectopically produce human IL-6, and in mice reconstituted with a human immune system. We show that a subset of DLBCL cases have evolved mechanisms that ensure constitutive activation of the IL-6 signaling pathway, i.e., the expression of both chains of the IL-6R, the expression of the cytokine itself, and the mutational inactivation of a negative regulator of IL-6 signaling, SOCS1. IL-6 signaling promotes MYC-driven lymphomagenesis in a genetically engineered model, and treatment with the IL-6R-specific antibody tocilizumab reduces growth of primary DLBCL cells and of DLBCL cell lines in various therapeutic settings. The combined results uncover the IL-6 signaling pathway as a driver and negative prognosticator in aggressive DLBCL that can be targeted with a safe and well-tolerated biologic."xsd:string |
| http://purl.uniprot.org/citations/31515941 | http://purl.org/dc/terms/identifier | "doi:10.15252/emmm.201910576"xsd:string |
| http://purl.uniprot.org/citations/31515941 | http://purl.uniprot.org/core/author | "Muller A."xsd:string |
| http://purl.uniprot.org/citations/31515941 | http://purl.uniprot.org/core/author | "Bertram K."xsd:string |
| http://purl.uniprot.org/citations/31515941 | http://purl.uniprot.org/core/author | "Wu C.T."xsd:string |
| http://purl.uniprot.org/citations/31515941 | http://purl.uniprot.org/core/author | "Manz M.G."xsd:string |
| http://purl.uniprot.org/citations/31515941 | http://purl.uniprot.org/core/author | "Stelling A."xsd:string |
| http://purl.uniprot.org/citations/31515941 | http://purl.uniprot.org/core/author | "Tzankov A."xsd:string |
| http://purl.uniprot.org/citations/31515941 | http://purl.uniprot.org/core/author | "Theocharides A.P."xsd:string |
| http://purl.uniprot.org/citations/31515941 | http://purl.uniprot.org/core/author | "Hashwah H."xsd:string |
| http://purl.uniprot.org/citations/31515941 | http://purl.uniprot.org/core/author | "Kasser S."xsd:string |
| http://purl.uniprot.org/citations/31515941 | http://purl.uniprot.org/core/author | "Stirm K."xsd:string |
| http://purl.uniprot.org/citations/31515941 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31515941 | http://purl.uniprot.org/core/name | "EMBO Mol Med"xsd:string |
| http://purl.uniprot.org/citations/31515941 | http://purl.uniprot.org/core/pages | "e10576"xsd:string |
| http://purl.uniprot.org/citations/31515941 | http://purl.uniprot.org/core/title | "The IL-6 signaling complex is a critical driver, negative prognostic factor, and therapeutic target in diffuse large B-cell lymphoma."xsd:string |
| http://purl.uniprot.org/citations/31515941 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/31515941 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31515941 |
| http://purl.uniprot.org/citations/31515941 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31515941 |
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| http://purl.uniprot.org/uniprot/#_E0CXQ9-mappedCitation-31515941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31515941 |
| http://purl.uniprot.org/uniprot/#_Q0PMN1-mappedCitation-31515941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31515941 |