Results

RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/31519589http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31519589http://www.w3.org/2000/01/rdf-schema#comment"

Background/aim

Hypoxia promotes tumor proliferation and metastasis in colorectal cancer (CRC). Since the tumor microenvironment is generally characterized by hypoxia, its understanding is important for cancer therapy. We hypothesized that hypoxia promotes the mitochondrial function, mobility, and proliferation of CRC by up-regulating peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α).

Materials and methods

To assess the effects of PGC-1α under hypoxia, we investigated the mitochondrial function, cell motility, and sphere formation as well as proliferation and apoptosis of CRC.

Results

Under hypoxia, we confirmed the increased expression of PGC-1α and reduced production of reactive oxygen species (ROS) by activating anti-oxidant enzymes. Also, up-regulation of PGC-1α enhanced the motility, sphere formation, and proliferation of CRC. Under the presence of the anti-cancer drug 5-fluorouracil (5FU), up-regulation of PGC-1α under hypoxia promoted resistance of CRC against 5FU-induced apoptosis.

Conclusion

Targeting PGC-1α could to be a powerful strategy for CRC therapy."xsd:string
http://purl.uniprot.org/citations/31519589http://purl.org/dc/terms/identifier"doi:10.21873/anticanres.13672"xsd:string
http://purl.uniprot.org/citations/31519589http://purl.uniprot.org/core/author"Lee J.H."xsd:string
http://purl.uniprot.org/citations/31519589http://purl.uniprot.org/core/author"Lee S.H."xsd:string
http://purl.uniprot.org/citations/31519589http://purl.uniprot.org/core/author"Yun C.W."xsd:string
http://purl.uniprot.org/citations/31519589http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/31519589http://purl.uniprot.org/core/name"Anticancer Res"xsd:string
http://purl.uniprot.org/citations/31519589http://purl.uniprot.org/core/pages"4865-4876"xsd:string
http://purl.uniprot.org/citations/31519589http://purl.uniprot.org/core/title"Hypoxia-induced PGC-1alpha Regulates Mitochondrial Function and Tumorigenesis of Colorectal Cancer Cells."xsd:string
http://purl.uniprot.org/citations/31519589http://purl.uniprot.org/core/volume"39"xsd:string
http://purl.uniprot.org/citations/31519589http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/31519589
http://purl.uniprot.org/citations/31519589http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/31519589
http://purl.uniprot.org/uniprot/#_B7Z7E0-mappedCitation-31519589http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31519589
http://purl.uniprot.org/uniprot/#_Q9UBK2-mappedCitation-31519589http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31519589
http://purl.uniprot.org/uniprot/Q9UBK2http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/31519589
http://purl.uniprot.org/uniprot/B7Z7E0http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/31519589