| http://purl.uniprot.org/citations/31526479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31526479 | http://www.w3.org/2000/01/rdf-schema#comment | "Epithelial homeostasis and regeneration require a pool of quiescent cells. How the quiescent cells are established and maintained is poorly understood. Here, we report that Trpv6, a cation channel responsible for epithelial Ca2+ absorption, functions as a key regulator of cellular quiescence. Genetic deletion and pharmacological blockade of Trpv6 promoted zebrafish epithelial cells to exit from quiescence and re-enter the cell cycle. Reintroducing Trpv6, but not its channel dead mutant, restored the quiescent state. Ca2+ imaging showed that Trpv6 is constitutively open in vivo. Mechanistically, Trpv6-mediated Ca2+ influx maintained the quiescent state by suppressing insulin-like growth factor (IGF)-mediated Akt-Tor and Erk signaling. In zebrafish epithelia and human colon carcinoma cells, Trpv6/TRPV6 elevated intracellular Ca2+ levels and activated PP2A, which down-regulated IGF signaling and promoted the quiescent state. Our findings suggest that Trpv6 mediates constitutive Ca2+ influx into epithelial cells to continuously suppress growth factor signaling and maintain the quiescent state."xsd:string |
| http://purl.uniprot.org/citations/31526479 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.48003"xsd:string |
| http://purl.uniprot.org/citations/31526479 | http://purl.uniprot.org/core/author | "Hu M."xsd:string |
| http://purl.uniprot.org/citations/31526479 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/31526479 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
| http://purl.uniprot.org/citations/31526479 | http://purl.uniprot.org/core/author | "Xin Y."xsd:string |
| http://purl.uniprot.org/citations/31526479 | http://purl.uniprot.org/core/author | "Duan C."xsd:string |
| http://purl.uniprot.org/citations/31526479 | http://purl.uniprot.org/core/author | "Malick A."xsd:string |
| http://purl.uniprot.org/citations/31526479 | http://purl.uniprot.org/core/author | "Batah H."xsd:string |
| http://purl.uniprot.org/citations/31526479 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31526479 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/31526479 | http://purl.uniprot.org/core/pages | "e48003"xsd:string |
| http://purl.uniprot.org/citations/31526479 | http://purl.uniprot.org/core/title | "Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6."xsd:string |
| http://purl.uniprot.org/citations/31526479 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/31526479 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31526479 |
| http://purl.uniprot.org/citations/31526479 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31526479 |
| http://purl.uniprot.org/uniprot/Q6JQN0#attribution-42F84E5C3172D43D64A0EC5AC502C9EB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/31526479 |
| http://purl.uniprot.org/uniprot/Q6JQN0#attribution-7F34E41BA43BBEEED4C098007957CDC9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/31526479 |
| http://purl.uniprot.org/uniprot/F1QN56#attribution-42F84E5C3172D43D64A0EC5AC502C9EB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/31526479 |
| http://purl.uniprot.org/uniprot/F1QN56#attribution-7F34E41BA43BBEEED4C098007957CDC9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/31526479 |
| http://purl.uniprot.org/uniprot/#_F1QN56-mappedCitation-31526479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31526479 |
| http://purl.uniprot.org/uniprot/#_Q6JQN0-mappedCitation-31526479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31526479 |
| http://purl.uniprot.org/uniprot/F1QN56 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31526479 |
| http://purl.uniprot.org/uniprot/Q6JQN0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31526479 |