| http://purl.uniprot.org/citations/31527146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31527146 | http://www.w3.org/2000/01/rdf-schema#comment | "The accurate regulation of phosphorylation at the kinetochore is essential for establishing chromosome bi-orientation. Phosphorylation of kinetochore proteins by the Aurora B kinase destabilizes improper kinetochore-microtubule attachments, whereas the phosphatase PP2A has a counteracting role. Imbalanced phosphoregulation leads to error-prone chromosome segregation and aneuploidy, a hallmark of cancer cells. However, little is known about the molecular events that control the balance of phosphorylation at the kinetochore. Here, we show that localization of SET/TAF1, an oncogene product, to centromeres maintains Aurora B kinase activity by inhibiting PP2A, thereby correcting erroneous kinetochore-microtubule attachment. SET localizes at the inner centromere by interacting directly with shugoshin 2, with SET levels declining at increased distances between kinetochore pairs, leading to establishment of chromosome bi-orientation. Moreover, SET overexpression induces chromosomal instability by disrupting kinetochore-microtubule attachment. Thus, our findings reveal the novel role of SET in fine-tuning the phosphorylation level at the kinetochore by balancing the activities of Aurora B and PP2A."xsd:string |
| http://purl.uniprot.org/citations/31527146 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201811060"xsd:string |
| http://purl.uniprot.org/citations/31527146 | http://purl.uniprot.org/core/author | "Watanabe Y."xsd:string |
| http://purl.uniprot.org/citations/31527146 | http://purl.uniprot.org/core/author | "Watanabe A."xsd:string |
| http://purl.uniprot.org/citations/31527146 | http://purl.uniprot.org/core/author | "Nagata K."xsd:string |
| http://purl.uniprot.org/citations/31527146 | http://purl.uniprot.org/core/author | "Fukuchi K."xsd:string |
| http://purl.uniprot.org/citations/31527146 | http://purl.uniprot.org/core/author | "Noda Y."xsd:string |
| http://purl.uniprot.org/citations/31527146 | http://purl.uniprot.org/core/author | "Asai Y."xsd:string |
| http://purl.uniprot.org/citations/31527146 | http://purl.uniprot.org/core/author | "Koizumi T."xsd:string |
| http://purl.uniprot.org/citations/31527146 | http://purl.uniprot.org/core/author | "Tanno Y."xsd:string |
| http://purl.uniprot.org/citations/31527146 | http://purl.uniprot.org/core/author | "Terada Y."xsd:string |
| http://purl.uniprot.org/citations/31527146 | http://purl.uniprot.org/core/author | "Matsumura R."xsd:string |
| http://purl.uniprot.org/citations/31527146 | http://purl.uniprot.org/core/author | "Kiyozuka T."xsd:string |
| http://purl.uniprot.org/citations/31527146 | http://purl.uniprot.org/core/author | "Koitabashi-Kiyozuka S."xsd:string |
| http://purl.uniprot.org/citations/31527146 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31527146 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/31527146 | http://purl.uniprot.org/core/pages | "3223-3236"xsd:string |
| http://purl.uniprot.org/citations/31527146 | http://purl.uniprot.org/core/title | "Aurora B kinase activity is regulated by SET/TAF1 on Sgo2 at the inner centromere."xsd:string |
| http://purl.uniprot.org/citations/31527146 | http://purl.uniprot.org/core/volume | "218"xsd:string |
| http://purl.uniprot.org/citations/31527146 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31527146 |
| http://purl.uniprot.org/citations/31527146 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31527146 |
| http://purl.uniprot.org/uniprot/#_A0A8J8YYJ1-mappedCitation-31527146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31527146 |
| http://purl.uniprot.org/uniprot/#_B7Z7S9-mappedCitation-31527146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31527146 |
| http://purl.uniprot.org/uniprot/#_B2RCX0-mappedCitation-31527146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31527146 |