| http://purl.uniprot.org/citations/31534009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31534009 | http://www.w3.org/2000/01/rdf-schema#comment | "The AM14 BCR, derived from an autoimmune MRL/lpr mouse, binds autologous IgG2aa/j with low affinity, and as a result, AM14 B cells only proliferate in response to IgG2a immune complexes that incorporate DNA, RNA, or nucleic acid-binding proteins that serve as autoadjuvants. As such, AM14 B cells have served as a useful model for demonstrating the importance of BCR/TLR coengagement in the activation of autoreactive B cells. We now show that the same receptor recognizes an additional murine-encoded Ag, expressed by B6 splenocytes, with sufficient avidity to induce a TLR-independent proliferative response of BALB/c AM14 Vκ8 B cells both in vivo and in vitro. Moreover, detection of this cross-reactive Ag by B6 AM14 Vκ8 B cells promotes an anergic phenotype as reflected by suboptimal responses to BCR cross-linking and the absence of mature B cells in the bone marrow. The B6 Ag further impacts B cell development as shown by a dramatically expanded marginal zone compartment and extensive receptor editing in B6 AM14 Vκ8 mice but not BALB/c AM14 Vκ8 mice. Despite their anergic phenotypes, B6 AM14 Vκ8 B cells can respond robustly to autoantigen/autoadjuvant immune complexes and could therefore participate in both autoimmune responses and host defense."xsd:string |
| http://purl.uniprot.org/citations/31534009 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1900499"xsd:string |
| http://purl.uniprot.org/citations/31534009 | http://purl.uniprot.org/core/author | "Schmidt M.R."xsd:string |
| http://purl.uniprot.org/citations/31534009 | http://purl.uniprot.org/core/author | "Shlomchik M.J."xsd:string |
| http://purl.uniprot.org/citations/31534009 | http://purl.uniprot.org/core/author | "Marshak-Rothstein A."xsd:string |
| http://purl.uniprot.org/citations/31534009 | http://purl.uniprot.org/core/author | "Busto P."xsd:string |
| http://purl.uniprot.org/citations/31534009 | http://purl.uniprot.org/core/author | "Woodland R.T."xsd:string |
| http://purl.uniprot.org/citations/31534009 | http://purl.uniprot.org/core/author | "Cullen J.L."xsd:string |
| http://purl.uniprot.org/citations/31534009 | http://purl.uniprot.org/core/author | "Nundel K."xsd:string |
| http://purl.uniprot.org/citations/31534009 | http://purl.uniprot.org/core/author | "Mande P."xsd:string |
| http://purl.uniprot.org/citations/31534009 | http://purl.uniprot.org/core/author | "Moses S.L."xsd:string |
| http://purl.uniprot.org/citations/31534009 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31534009 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/31534009 | http://purl.uniprot.org/core/pages | "ji1900499"xsd:string |
| http://purl.uniprot.org/citations/31534009 | http://purl.uniprot.org/core/title | "Cross-Reactive Antigen Expressed by B6 Splenocytes Drives Receptor Editing and Marginal Zone Differentiation of IgG2a-Reactive AM14 Vkappa8 B Cells."xsd:string |
| http://purl.uniprot.org/citations/31534009 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31534009 |
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