| http://purl.uniprot.org/citations/31535973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31535973 | http://www.w3.org/2000/01/rdf-schema#comment | "In most vertebrates, the upper digestive tract is composed of muscularized jaws linked to the esophagus that permits food ingestion and swallowing. Masticatory and esophagus striated muscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, however ESM are unusual among striated muscles as they are established in the absence of a primary skeletal muscle scaffold. Using mouse chimeras, we show that the transcription factors Tbx1 and Isl1 are required cell-autonomously for myogenic specification of ESM progenitors. Further, genetic loss-of-function and pharmacological studies point to MET/HGF signaling for antero-posterior migration of esophagus muscle progenitors, where Hgf ligand is expressed in adjacent smooth muscle cells. These observations highlight the functional relevance of a smooth and striated muscle progenitor dialogue for ESM patterning. Our findings establish a Tbx1-Isl1-Met genetic hierarchy that uniquely regulates esophagus myogenesis and identify distinct genetic signatures that can be used as framework to interpret pathologies arising within CPM derivatives."xsd:string |
| http://purl.uniprot.org/citations/31535973 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.47460"xsd:string |
| http://purl.uniprot.org/citations/31535973 | http://purl.uniprot.org/core/author | "Comai G."xsd:string |
| http://purl.uniprot.org/citations/31535973 | http://purl.uniprot.org/core/author | "Tajbakhsh S."xsd:string |
| http://purl.uniprot.org/citations/31535973 | http://purl.uniprot.org/core/author | "Gopalakrishnan S."xsd:string |
| http://purl.uniprot.org/citations/31535973 | http://purl.uniprot.org/core/author | "Gallardo M."xsd:string |
| http://purl.uniprot.org/citations/31535973 | http://purl.uniprot.org/core/author | "Kardon G."xsd:string |
| http://purl.uniprot.org/citations/31535973 | http://purl.uniprot.org/core/author | "Pala F."xsd:string |
| http://purl.uniprot.org/citations/31535973 | http://purl.uniprot.org/core/author | "Langa F."xsd:string |
| http://purl.uniprot.org/citations/31535973 | http://purl.uniprot.org/core/author | "Mella S."xsd:string |
| http://purl.uniprot.org/citations/31535973 | http://purl.uniprot.org/core/author | "Heude E."xsd:string |
| http://purl.uniprot.org/citations/31535973 | http://purl.uniprot.org/core/author | "Paisant S."xsd:string |
| http://purl.uniprot.org/citations/31535973 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31535973 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/31535973 | http://purl.uniprot.org/core/pages | "e47460"xsd:string |
| http://purl.uniprot.org/citations/31535973 | http://purl.uniprot.org/core/title | "A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle."xsd:string |
| http://purl.uniprot.org/citations/31535973 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/31535973 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31535973 |
| http://purl.uniprot.org/citations/31535973 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31535973 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1A8-mappedCitation-31535973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31535973 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1B0-mappedCitation-31535973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31535973 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1B1-mappedCitation-31535973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31535973 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RM76-mappedCitation-31535973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31535973 |
| http://purl.uniprot.org/uniprot/#_D3YVY2-mappedCitation-31535973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31535973 |