| http://purl.uniprot.org/citations/31536487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31536487 | http://www.w3.org/2000/01/rdf-schema#comment | "Transient receptor potential (TRP) proteins form Ca2+-permeable, nonselective cation channels, but their role in neuronal Ca2+ homeostasis is elusive. In the present paper, we show that TRPC channels potently regulate synaptic plasticity by changing the presynaptic Ca2+-homeostasis of hippocampal neurons. Specifically, loss of TRPC1/C4/C5 channels decreases basal-evoked secretion, reduces the pool size of readily releasable vesicles, and accelerates synaptic depression during high-frequency stimulation (HFS). In contrast, primary TRPC5 channel-expressing neurons, identified by a novel TRPC5-τ-green fluorescent protein (τGFP) knockin mouse line, show strong short-term enhancement (STE) of synaptic signaling during HFS, indicating a key role of TRPC5 in short-term plasticity. Lentiviral expression of either TRPC1 or TRPC5 turns classic synaptic depression of wild-type neurons into STE, demonstrating that TRPCs are instrumental in regulating synaptic plasticity. Presynaptic Ca2+ imaging shows that TRPC activity strongly boosts synaptic Ca2+ dynamics, showing that TRPC channels provide an additional presynaptic Ca2+ entry pathway, which efficiently regulates synaptic strength and plasticity."xsd:string |
| http://purl.uniprot.org/citations/31536487 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.3000445"xsd:string |
| http://purl.uniprot.org/citations/31536487 | http://purl.uniprot.org/core/author | "Flockerzi V."xsd:string |
| http://purl.uniprot.org/citations/31536487 | http://purl.uniprot.org/core/author | "Wyatt A."xsd:string |
| http://purl.uniprot.org/citations/31536487 | http://purl.uniprot.org/core/author | "Freichel M."xsd:string |
| http://purl.uniprot.org/citations/31536487 | http://purl.uniprot.org/core/author | "Bruns D."xsd:string |
| http://purl.uniprot.org/citations/31536487 | http://purl.uniprot.org/core/author | "Boehm U."xsd:string |
| http://purl.uniprot.org/citations/31536487 | http://purl.uniprot.org/core/author | "Weissgerber P."xsd:string |
| http://purl.uniprot.org/citations/31536487 | http://purl.uniprot.org/core/author | "Schwarz Y."xsd:string |
| http://purl.uniprot.org/citations/31536487 | http://purl.uniprot.org/core/author | "Oleinikov K."xsd:string |
| http://purl.uniprot.org/citations/31536487 | http://purl.uniprot.org/core/author | "Schindeldecker B."xsd:string |
| http://purl.uniprot.org/citations/31536487 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31536487 | http://purl.uniprot.org/core/name | "PLoS Biol"xsd:string |
| http://purl.uniprot.org/citations/31536487 | http://purl.uniprot.org/core/pages | "e3000445"xsd:string |
| http://purl.uniprot.org/citations/31536487 | http://purl.uniprot.org/core/title | "TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses."xsd:string |
| http://purl.uniprot.org/citations/31536487 | http://purl.uniprot.org/core/volume | "17"xsd:string |
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