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http://purl.uniprot.org/citations/31537466http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31537466http://www.w3.org/2000/01/rdf-schema#comment"

Background/objective

Hemophilia A is a genetic disorder through which patients suffer from recurrent bleeding. This can be caused by a defect in human plasma coagulation factor VIII. High incidence of FVIII inhibitors in some severe hemophilia A patients after FVIII therapy is a considerable complication. Determination of good predictive factors can improve the safety of this treatment. HLA-II have been shown as a predictive element for inhibitor development. The goal of this study is to determine the association between HLA-DRB1*15:03, HLA-DRB1*11 and HLA-DRB1*01:01 alleles and FVIII inhibitors in severe hemophilia A patients in Iran.

Materials/methods

HLA-DRB1 genotyping was performed using Multiplex sequences Specific Primers (PCR-SSP) in two groups of severe hemophilia A patients comprising 51 and 50 individuals with and without FVIII inhibitors respectively. The levels of inhibitor were determined through Nijmegen-modified Bethesda assay. HLA-DRB1 allele frequencies were compared between groups by using multiple logistic regression models.

Results

HLA-DRB1*01:01 allele frequency was significantly higher in patients without inhibitor ORadj: 2.7 (95%CI: 1.08, 6.97; P = 0.034). There wasn't any statistically significant difference in HLA-DRB1*11 allele frequency between groups ORadj: 0.7 (95%CI: 0.27, 1.82; P = 0.47). There was no connection between HLA-DRB1*15:03 and inhibitor development ORadj: 0.94 (95%CI: 0.38, 2.35; P = 0.94).

Conclusion

An association between HLA-DRB1*01:01 and paucity of FVIII inhibitor showed that this allele has probably a protective effect in severe hemophilia A patients in Iran. Determination of the predictive and protective alleles are beneficial in pre-treatment activities and decrease the risk of unsuccessful therapy with FVIII in each population."xsd:string
http://purl.uniprot.org/citations/31537466http://purl.org/dc/terms/identifier"doi:10.1016/j.transci.2019.08.019"xsd:string
http://purl.uniprot.org/citations/31537466http://purl.uniprot.org/core/author"Aghaie A."xsd:string
http://purl.uniprot.org/citations/31537466http://purl.uniprot.org/core/author"Hosseini S."xsd:string
http://purl.uniprot.org/citations/31537466http://purl.uniprot.org/core/author"Yari F."xsd:string
http://purl.uniprot.org/citations/31537466http://purl.uniprot.org/core/author"Rezaie N."xsd:string
http://purl.uniprot.org/citations/31537466http://purl.uniprot.org/core/author"Arabi S."xsd:string
http://purl.uniprot.org/citations/31537466http://purl.uniprot.org/core/author"Moazezi S."xsd:string
http://purl.uniprot.org/citations/31537466http://purl.uniprot.org/core/author"Pourfatollah A."xsd:string
http://purl.uniprot.org/citations/31537466http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/31537466http://purl.uniprot.org/core/name"Transfus Apher Sci"xsd:string
http://purl.uniprot.org/citations/31537466http://purl.uniprot.org/core/pages"669-673"xsd:string
http://purl.uniprot.org/citations/31537466http://purl.uniprot.org/core/title"HLA-DRB1*01:01, but not HLA-DRB1:1503 or HLA-DRB1*11, is associated with decreased inhibitor risk in Iranian hemophilia A patients."xsd:string
http://purl.uniprot.org/citations/31537466http://purl.uniprot.org/core/volume"58"xsd:string
http://purl.uniprot.org/citations/31537466http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/31537466
http://purl.uniprot.org/citations/31537466http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/31537466
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