| http://purl.uniprot.org/citations/31537712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31537712 | http://www.w3.org/2000/01/rdf-schema#comment | "Binding of kindlins to integrins is required for integrin activation, stable ligand binding, and subsequent intracellular signaling. How hematopoietic kindlin-3 contributes to the assembly and stability of the adhesion complex is not known. Here we report that kindlin-3 recruits leupaxin into podosomes and thereby regulates paxillin phosphorylation and podosome turnover. We demonstrate that the activity of the protein tyrosine phosphatase PTP-PEST, which controls paxillin phosphorylation, requires leupaxin. In contrast, despite sharing the same binding mode with leupaxin, paxillin recruitment into podosomes is kindlin-3 independent. Instead, we found paxillin together with talin and vinculin in initial adhesion patches of kindlin-3-null cells. Surprisingly, despite its presence in these early adhesion patches, podosomes can form in the absence of paxillin or any paxillin member. In conclusion, our findings show that kindlin-3 not only activates and clusters integrins into podosomes but also regulates their lifetime by recruiting leupaxin, which controls PTP-PEST activity and thereby paxillin phosphorylation and downstream signaling."xsd:string |
| http://purl.uniprot.org/citations/31537712 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201903109"xsd:string |
| http://purl.uniprot.org/citations/31537712 | http://purl.uniprot.org/core/author | "Kruger M."xsd:string |
| http://purl.uniprot.org/citations/31537712 | http://purl.uniprot.org/core/author | "Turk C."xsd:string |
| http://purl.uniprot.org/citations/31537712 | http://purl.uniprot.org/core/author | "Moser M."xsd:string |
| http://purl.uniprot.org/citations/31537712 | http://purl.uniprot.org/core/author | "Klapproth S."xsd:string |
| http://purl.uniprot.org/citations/31537712 | http://purl.uniprot.org/core/author | "Bromberger T."xsd:string |
| http://purl.uniprot.org/citations/31537712 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31537712 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/31537712 | http://purl.uniprot.org/core/pages | "3436-3454"xsd:string |
| http://purl.uniprot.org/citations/31537712 | http://purl.uniprot.org/core/title | "A kindlin-3-leupaxin-paxillin signaling pathway regulates podosome stability."xsd:string |
| http://purl.uniprot.org/citations/31537712 | http://purl.uniprot.org/core/volume | "218"xsd:string |
| http://purl.uniprot.org/citations/31537712 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31537712 |
| http://purl.uniprot.org/citations/31537712 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31537712 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTZ8-mappedCitation-31537712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31537712 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV30-mappedCitation-31537712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31537712 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV66-mappedCitation-31537712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31537712 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RMM8-mappedCitation-31537712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31537712 |
| http://purl.uniprot.org/uniprot/#_A0A494B990-mappedCitation-31537712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31537712 |
| http://purl.uniprot.org/uniprot/#_A0A494B9F7-mappedCitation-31537712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31537712 |
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| http://purl.uniprot.org/uniprot/#_A0A494BBJ8-mappedCitation-31537712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31537712 |
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| http://purl.uniprot.org/uniprot/#_O88294-mappedCitation-31537712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31537712 |