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http://purl.uniprot.org/citations/31541338http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31541338http://www.w3.org/2000/01/rdf-schema#comment"

Background

It is known that there are insufficient prognostic factors for non-small cell lung cancer (NSCLC). It was reported that PD-L1 was a prognostic factor for NSCLC,and c-Myc regulated the expression of PD-L1. Herein, we investigated c-Myc and PD-L1 expression and their association with overall survival (OS) in NSCLC.

Methods

Formalin-fixed paraffin-embedded specimens were obtained from 128 patients with surgically resected primary NSCLC. Immunohistochemistry was used to assess the expression of PD-L1 and c-Myc in this study. Pearson's Chi squared test or Fisher's exact test was used to analyze the correlation of the expression of PD-L1 and c-Myc with clinicopathologic features. The relationship between OS and the expression of PD-L1 and c-Myc was evaluated by the Kaplan-Meier method and Cox proportional hazards model, respectively.

Results

Positive expression of PD-L1 was detected in 59 patients (46.1%). Patients with negative expression of PD-L1 had remarkably longer OS than those with positive expression of PD-L1. The positive expression rate of c-Myc in NSCLC accounted for 58.6% (75/128) and its expression was significantly more frequent in males (p = 0.002) and patients with lymph node metastasis (p = 0.029). PD-L1 expression was positively correlated with c-Myc expression (r = 0.459, p < 0.001). The PD-L1 and c-Myc double-positive group had a worse prognosis than other subgroups (p < 0.05), and the PD-L1 and c-Myc double-negative group had a better OS than other subgroups (p < 0.05).

Conclusion

Conjoint analysis of the expression of PD-L1 and c-Myc was a better prognostic approach for NSCLC patients."xsd:string
http://purl.uniprot.org/citations/31541338http://purl.org/dc/terms/identifier"doi:10.1007/s00432-019-03025-8"xsd:string
http://purl.uniprot.org/citations/31541338http://purl.uniprot.org/core/author"Ma H."xsd:string
http://purl.uniprot.org/citations/31541338http://purl.uniprot.org/core/author"Cong Y."xsd:string
http://purl.uniprot.org/citations/31541338http://purl.uniprot.org/core/author"Qiu J."xsd:string
http://purl.uniprot.org/citations/31541338http://purl.uniprot.org/core/author"Sun H."xsd:string
http://purl.uniprot.org/citations/31541338http://purl.uniprot.org/core/author"Zhang H."xsd:string
http://purl.uniprot.org/citations/31541338http://purl.uniprot.org/core/author"Zhou C."xsd:string
http://purl.uniprot.org/citations/31541338http://purl.uniprot.org/core/author"Xie Z."xsd:string
http://purl.uniprot.org/citations/31541338http://purl.uniprot.org/core/author"Zheng X."xsd:string
http://purl.uniprot.org/citations/31541338http://purl.uniprot.org/core/author"Pei X."xsd:string
http://purl.uniprot.org/citations/31541338http://purl.uniprot.org/core/author"Che G."xsd:string
http://purl.uniprot.org/citations/31541338http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/31541338http://purl.uniprot.org/core/name"J Cancer Res Clin Oncol"xsd:string
http://purl.uniprot.org/citations/31541338http://purl.uniprot.org/core/pages"2663-2674"xsd:string
http://purl.uniprot.org/citations/31541338http://purl.uniprot.org/core/title"Expression and clinical significance of PD-L1 and c-Myc in non-small cell lung cancer."xsd:string
http://purl.uniprot.org/citations/31541338http://purl.uniprot.org/core/volume"145"xsd:string
http://purl.uniprot.org/citations/31541338http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/31541338
http://purl.uniprot.org/citations/31541338http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/31541338
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