| http://purl.uniprot.org/citations/31545279 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31545279 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatocellular carcinoma (HCC) is the commonest primary liver cancer with highly aggressive features. MicroRNAs (miRNAs) are demonstrated to play important roles in the tumorigenesis and progression of HCC. miR-769-5p is a recently identified cancer-associated miRNA. But, the expression level of miR-769-5p and its function in HCC are unexplored. In this study, we found that miR-769-5p expression was obviously increased in HCC samples compared to adjacent noncancerous liver tissues. Additionally, we revealed that miR-769-5p was over-expressed in HCC cells as compared with LO2 cells. Notably, HCC tissues from patients with tumor size ≥5 cm, venous infiltration and advanced tumor stages showed higher levels of miR-769-5p compared to those from corresponding controls. Interestingly, our data indicated that HCC patients highly expressing miR-769-5p had significant shorter survivals. Next, functional experiments verified that miR-769-5p knockdown markedly suppressed HCC cell proliferation, migration and invasion. Conversely, ectopic expression of miR-769-5p promoted these biological behaviors of Hep3B cells. Furthermore, depletion of miR-769-5p repressed the growth and metastasis of HCCLM3 cells in vivo. Importantly, miR-769-5p inversely modulated RING1 and YY1 binding protein (RYBP) by directly binding to 3' untranslated region (UTR) in HCC cells. The expression of RYBP mRNA was down-regulated in HCC tissues and negatively correlated with miR-769-5p level. RYBP overexpression remarkably inhibited the proliferation, migration and invasion of HCCLM3 cells. Accordingly, knockdown of RYBP partially abolished miR-769-5p silencing-induced tumor suppressive effects on HCCLM3 cells. In summary, our study revealed the up-regulated expression of miR-769-5p, which contributed to HCC progression possibly by targeting RYBP."xsd:string |
| http://purl.uniprot.org/citations/31545279 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biopha.2019.109343"xsd:string |
| http://purl.uniprot.org/citations/31545279 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/31545279 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/31545279 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/31545279 | http://purl.uniprot.org/core/author | "Mo H."xsd:string |
| http://purl.uniprot.org/citations/31545279 | http://purl.uniprot.org/core/author | "Yao B."xsd:string |
| http://purl.uniprot.org/citations/31545279 | http://purl.uniprot.org/core/author | "Xian Y."xsd:string |
| http://purl.uniprot.org/citations/31545279 | http://purl.uniprot.org/core/author | "Tu K."xsd:string |
| http://purl.uniprot.org/citations/31545279 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31545279 | http://purl.uniprot.org/core/name | "Biomed Pharmacother"xsd:string |
| http://purl.uniprot.org/citations/31545279 | http://purl.uniprot.org/core/pages | "109343"xsd:string |
| http://purl.uniprot.org/citations/31545279 | http://purl.uniprot.org/core/title | "MicroRNA-769-5p contributes to the proliferation, migration and invasion of hepatocellular carcinoma cells by attenuating RYBP."xsd:string |
| http://purl.uniprot.org/citations/31545279 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/31545279 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31545279 |
| http://purl.uniprot.org/citations/31545279 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31545279 |
| http://purl.uniprot.org/uniprot/#_Q8N488-mappedCitation-31545279 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31545279 |
| http://purl.uniprot.org/uniprot/#_L8ECE1-mappedCitation-31545279 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31545279 |
| http://purl.uniprot.org/uniprot/Q8N488 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31545279 |
| http://purl.uniprot.org/uniprot/L8ECE1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31545279 |