| http://purl.uniprot.org/citations/31546102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31546102 | http://www.w3.org/2000/01/rdf-schema#comment | "Orexins are hypothalamic neuropeptides that regulate feeding, energy expenditure, and sleep. Although orexin-deficient mice are susceptible to obesity, little is known about the roles of the orexin receptors in long-term energy metabolism. Here, we performed the metabolic characterization of orexin receptor-deficient mice. Ox1r-deficient mice were resistant to diet-induced obesity, and their food intake was similar between chow and high-fat food. Ox2r-deficient mice exhibited less energy expenditure than wild-type mice when fed a high-fat diet. Neither Ox1r-deficient nor Ox2r-deficient mice showed body weight gain similar to orexin-deficient mice. Although the presence of a running wheel suppressed diet-induced obesity in wild-type mice, the effect was weaker in orexin neuron-ablated mice. Finally, we did not detect abnormalities in brown adipose tissues of orexin-deficient mice. Thus, each orexin receptor signaling has a unique role in energy metabolism, and orexin neurons are involved in the interactive effect of diet and exercise on body weight gain."xsd:string |
| http://purl.uniprot.org/citations/31546102 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2019.09.003"xsd:string |
| http://purl.uniprot.org/citations/31546102 | http://purl.uniprot.org/core/author | "Kim S.J."xsd:string |
| http://purl.uniprot.org/citations/31546102 | http://purl.uniprot.org/core/author | "Takase K."xsd:string |
| http://purl.uniprot.org/citations/31546102 | http://purl.uniprot.org/core/author | "Yanagisawa M."xsd:string |
| http://purl.uniprot.org/citations/31546102 | http://purl.uniprot.org/core/author | "Abe M."xsd:string |
| http://purl.uniprot.org/citations/31546102 | http://purl.uniprot.org/core/author | "Choi J."xsd:string |
| http://purl.uniprot.org/citations/31546102 | http://purl.uniprot.org/core/author | "Tsuneoka Y."xsd:string |
| http://purl.uniprot.org/citations/31546102 | http://purl.uniprot.org/core/author | "Kakizaki M."xsd:string |
| http://purl.uniprot.org/citations/31546102 | http://purl.uniprot.org/core/author | "Sakimura K."xsd:string |
| http://purl.uniprot.org/citations/31546102 | http://purl.uniprot.org/core/author | "Funato H."xsd:string |
| http://purl.uniprot.org/citations/31546102 | http://purl.uniprot.org/core/author | "Ikkyu A."xsd:string |
| http://purl.uniprot.org/citations/31546102 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31546102 | http://purl.uniprot.org/core/name | "iScience"xsd:string |
| http://purl.uniprot.org/citations/31546102 | http://purl.uniprot.org/core/pages | "1-13"xsd:string |
| http://purl.uniprot.org/citations/31546102 | http://purl.uniprot.org/core/title | "Differential Roles of Each Orexin Receptor Signaling in Obesity."xsd:string |
| http://purl.uniprot.org/citations/31546102 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/31546102 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31546102 |
| http://purl.uniprot.org/citations/31546102 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31546102 |
| http://purl.uniprot.org/uniprot/#_Q0VDP6-mappedCitation-31546102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31546102 |
| http://purl.uniprot.org/uniprot/#_A2A5D9-mappedCitation-31546102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31546102 |
| http://purl.uniprot.org/uniprot/#_B2RU43-mappedCitation-31546102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31546102 |
| http://purl.uniprot.org/uniprot/#_P58307-mappedCitation-31546102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31546102 |
| http://purl.uniprot.org/uniprot/#_P58308-mappedCitation-31546102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31546102 |