| http://purl.uniprot.org/citations/31546103 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31546103 | http://www.w3.org/2000/01/rdf-schema#comment | "RNautophagy is a newly described type of selective autophagy whereby cellular RNAs are transported into lysosomes for degradation. This process involves the transmembrane protein SIDT2, which transports double-stranded RNA (dsRNA) across the endolysosomal membrane. We previously demonstrated that SIDT2 is a transcriptional target of p53, but its role in tumorigenesis, if any, is unclear. Unexpectedly, we show here that Sidt2-/- mice with concurrent oncogenic KrasG12D activation develop significantly fewer tumors than littermate controls in a mouse model of lung adenocarcinoma. Consistent with this observation, loss of SIDT2 also leads to enhanced survival and delayed tumor development in an Apcmin/+ mouse model of intestinal cancer. Within the intestine, Apcmin/+;Sidt2-/- mice display accumulation of dsRNA in association with increased phosphorylation of eIF2α and JNK as well as elevated rates of apoptosis. Taken together, our data demonstrate a role for SIDT2, and by extension RNautophagy, in promoting tumor development."xsd:string |
| http://purl.uniprot.org/citations/31546103 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2019.09.009"xsd:string |
| http://purl.uniprot.org/citations/31546103 | http://purl.uniprot.org/core/author | "Pang K.C."xsd:string |
| http://purl.uniprot.org/citations/31546103 | http://purl.uniprot.org/core/author | "Nguyen T.A."xsd:string |
| http://purl.uniprot.org/citations/31546103 | http://purl.uniprot.org/core/author | "Attardi L.D."xsd:string |
| http://purl.uniprot.org/citations/31546103 | http://purl.uniprot.org/core/author | "Wicks I.P."xsd:string |
| http://purl.uniprot.org/citations/31546103 | http://purl.uniprot.org/core/author | "Putoczki T.L."xsd:string |
| http://purl.uniprot.org/citations/31546103 | http://purl.uniprot.org/core/author | "Bieging-Rolett K.T."xsd:string |
| http://purl.uniprot.org/citations/31546103 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31546103 | http://purl.uniprot.org/core/name | "iScience"xsd:string |
| http://purl.uniprot.org/citations/31546103 | http://purl.uniprot.org/core/pages | "14-24"xsd:string |
| http://purl.uniprot.org/citations/31546103 | http://purl.uniprot.org/core/title | "SIDT2 RNA Transporter Promotes Lung and Gastrointestinal Tumor Development."xsd:string |
| http://purl.uniprot.org/citations/31546103 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/31546103 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31546103 |
| http://purl.uniprot.org/citations/31546103 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31546103 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVY1-mappedCitation-31546103 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31546103 |
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| http://purl.uniprot.org/uniprot/#_F7B6N2-mappedCitation-31546103 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31546103 |
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