| http://purl.uniprot.org/citations/31550181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31550181 | http://www.w3.org/2000/01/rdf-schema#comment | "Extracellular matrix hyaluronan is increased in skeletal muscle of high-fat-fed insulin-resistant mice, and reduction of hyaluronan by PEGPH20 hyaluronidase ameliorates diet-induced insulin resistance (IR). CD44, the main hyaluronan receptor, is positively correlated with type 2 diabetes. This study determines the role of CD44 in skeletal muscle IR. Global CD44-deficient (cd44-/-) mice and wild-type littermates (cd44+/+) were fed a chow diet or 60% high-fat diet for 16 wk. High-fat-fed cd44-/- mice were also treated with PEGPH20 to evaluate its CD44-dependent action. Insulin sensitivity was measured by hyperinsulinemic-euglycemic clamp (ICv). High-fat feeding increased muscle CD44 protein expression. In the absence of differences in body weight and composition, despite lower clamp insulin during ICv, the cd44-/- mice had sustained glucose infusion rate (GIR) regardless of diet. High-fat diet-induced muscle IR as evidenced by decreased muscle glucose uptake (Rg) was exhibited in cd44+/+ mice but absent in cd44-/- mice. Moreover, gastrocnemius Rg remained unchanged between genotypes on chow diet but was increased in high-fat-fed cd44-/- compared with cd44+/+ when normalized to clamp insulin concentrations. Ameliorated muscle IR in high-fat-fed cd44-/- mice was associated with increased vascularization. In contrast to previously observed increases in wild-type mice, PEGPH20 treatment in high-fat-fed cd44-/- mice did not change GIR or muscle Rg during ICv, suggesting a CD44-dependent action. In conclusion, genetic CD44 deletion improves muscle IR, and the beneficial effects of PEGPH20 are CD44-dependent. These results suggest a critical role of CD44 in promoting hyaluronan-mediated muscle IR, therefore representing a potential therapeutic target for diabetes."xsd:string |
| http://purl.uniprot.org/citations/31550181 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpendo.00215.2019"xsd:string |
| http://purl.uniprot.org/citations/31550181 | http://purl.uniprot.org/core/author | "Kang L."xsd:string |
| http://purl.uniprot.org/citations/31550181 | http://purl.uniprot.org/core/author | "Khan F."xsd:string |
| http://purl.uniprot.org/citations/31550181 | http://purl.uniprot.org/core/author | "Wasserman D.H."xsd:string |
| http://purl.uniprot.org/citations/31550181 | http://purl.uniprot.org/core/author | "Ashford M.L.J."xsd:string |
| http://purl.uniprot.org/citations/31550181 | http://purl.uniprot.org/core/author | "Hennayake C.K."xsd:string |
| http://purl.uniprot.org/citations/31550181 | http://purl.uniprot.org/core/author | "Bracy D.P."xsd:string |
| http://purl.uniprot.org/citations/31550181 | http://purl.uniprot.org/core/author | "McCrimmon R.J."xsd:string |
| http://purl.uniprot.org/citations/31550181 | http://purl.uniprot.org/core/author | "Lantier L."xsd:string |
| http://purl.uniprot.org/citations/31550181 | http://purl.uniprot.org/core/author | "Hasib A."xsd:string |
| http://purl.uniprot.org/citations/31550181 | http://purl.uniprot.org/core/author | "Bugler-Lamb A.R."xsd:string |
| http://purl.uniprot.org/citations/31550181 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31550181 | http://purl.uniprot.org/core/name | "Am J Physiol Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/31550181 | http://purl.uniprot.org/core/pages | "E973-E983"xsd:string |
| http://purl.uniprot.org/citations/31550181 | http://purl.uniprot.org/core/title | "CD44 contributes to hyaluronan-mediated insulin resistance in skeletal muscle of high-fat-fed C57BL/6 mice."xsd:string |
| http://purl.uniprot.org/citations/31550181 | http://purl.uniprot.org/core/volume | "317"xsd:string |
| http://purl.uniprot.org/citations/31550181 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31550181 |
| http://purl.uniprot.org/citations/31550181 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31550181 |
| http://purl.uniprot.org/uniprot/#_P15379-mappedCitation-31550181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31550181 |
| http://purl.uniprot.org/uniprot/#_A2APM1-mappedCitation-31550181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31550181 |
| http://purl.uniprot.org/uniprot/#_A2APM2-mappedCitation-31550181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31550181 |
| http://purl.uniprot.org/uniprot/#_A2APM3-mappedCitation-31550181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31550181 |
| http://purl.uniprot.org/uniprot/#_A2APM4-mappedCitation-31550181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31550181 |