| http://purl.uniprot.org/citations/31550518 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31550518 | http://www.w3.org/2000/01/rdf-schema#comment | "The expression and functional impact of most orphan G-protein coupled receptors (GPCRs) in β-cell is not fully understood. Microarray expression indicated that 36 orphan GPCRs are restricted in human islets, while 55 receptors overlapped between human islets and INS-1 cells. GPR183 showed higher expression in diabetic compared to non-diabetic human islets. GPR183 expression co-localized with β-cells while it was lacking in α-cells in human islets. The GPR183 agonist (7α-25-DHC) potentiated insulin secretion and protected against glucotoxicity-induced β-cell damage in human islets. Silencing of GPR183 in INS-1 cells decreased the expression of proinsulin genes, Pdx1, Mafa and impaired insulin secretion with a concomitant decrease in cAMP generation. Cultured INS-1 cells with 7α-25-DHC were associated with increased proliferation and expression of GPR183, INS2, PDX1, NeuroD, and INSR. In conclusion, the beneficial impact of GPR183 activation on β-cell function makes it a potential therapeutic target to prevent or reverse β-cell dysfunction."xsd:string |
| http://purl.uniprot.org/citations/31550518 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mce.2019.110592"xsd:string |
| http://purl.uniprot.org/citations/31550518 | http://purl.uniprot.org/core/author | "Hamad M."xsd:string |
| http://purl.uniprot.org/citations/31550518 | http://purl.uniprot.org/core/author | "Malek A."xsd:string |
| http://purl.uniprot.org/citations/31550518 | http://purl.uniprot.org/core/author | "Salehi A."xsd:string |
| http://purl.uniprot.org/citations/31550518 | http://purl.uniprot.org/core/author | "Mohammed I."xsd:string |
| http://purl.uniprot.org/citations/31550518 | http://purl.uniprot.org/core/author | "Duner P."xsd:string |
| http://purl.uniprot.org/citations/31550518 | http://purl.uniprot.org/core/author | "Taneera J."xsd:string |
| http://purl.uniprot.org/citations/31550518 | http://purl.uniprot.org/core/author | "Mohammed A.K."xsd:string |
| http://purl.uniprot.org/citations/31550518 | http://purl.uniprot.org/core/author | "Elemam N.M."xsd:string |
| http://purl.uniprot.org/citations/31550518 | http://purl.uniprot.org/core/author | "Sulaiman N."xsd:string |
| http://purl.uniprot.org/citations/31550518 | http://purl.uniprot.org/core/author | "Dhaiban S."xsd:string |
| http://purl.uniprot.org/citations/31550518 | http://purl.uniprot.org/core/author | "Hachim M."xsd:string |
| http://purl.uniprot.org/citations/31550518 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31550518 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/31550518 | http://purl.uniprot.org/core/pages | "110592"xsd:string |
| http://purl.uniprot.org/citations/31550518 | http://purl.uniprot.org/core/title | "Orphan G-protein coupled receptor 183 (GPR183) potentiates insulin secretion and prevents glucotoxicity-induced beta-cell dysfunction."xsd:string |
| http://purl.uniprot.org/citations/31550518 | http://purl.uniprot.org/core/volume | "499"xsd:string |
| http://purl.uniprot.org/citations/31550518 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31550518 |
| http://purl.uniprot.org/citations/31550518 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31550518 |
| http://purl.uniprot.org/uniprot/#_P32249-mappedCitation-31550518 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31550518 |
| http://purl.uniprot.org/uniprot/P32249 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31550518 |