| http://purl.uniprot.org/citations/31550807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31550807 | http://www.w3.org/2000/01/rdf-schema#comment | "Objective: To assess the methylation level of SHP-1 promoter region and the effects on the phosphorylation of the Signal Transducers and Activators of Transcription 3 (STAT3) protein in bone marrow specimen of patients with myelodysplastic syndrome (MDS), and to explore the relationship of SHP-1 methylation and prognosis of the patients. Method: Bone marrow specimens of 93 patients with MDS were collected from the General Hospital of Tianjin Medical University from September 2010 to June 2014. The enrolled subjects included 54 males and 39 females and they were divided into the low-risk group (IPSS score:0-1.0, median: 0.5) and the high-risk group (IPSS score: 1.5-3.0, median: 2.5) according to the International Prognostic Score System (IPSS). The methylation level of SHP-1 was detected by methylation-specific polymerase chain reaction, and the level of p-STAT3 was detected using Western blot. Results: In the high-risk group, 64.44% (29/45) of the patients had methylation in the SHP-1 promoter region, which was significantly higher than the low-risk group 22.92% (11/48). Therefore, SHP-1 methylation was frequently presented in the patients of the high-risk group. Similarly, 66.67% (30/45) of the patients in the high-risk group had positive STAT3 phosphorylation status, whereas only 20.83% (10/48) were tested positive in the low-risk group. In addition, correlation analysis also revealed that the SHP-1 methylation rate was positively correlated with the positive rate of STAT3 phosphorylation (r=0.57,P<0.001). Conclusions: SHP-1 methylation is significantly correlated with the risk of MDS patients. It may be used as an independent predictor of shorter survival in patients of the high-risk group. The increased level of SHP-1 methylation will lead to the uncontrolled activation of the downstream JAK/STAT3 pathway, which in turn can cause further positive feedback to amplify the carcinogenic signal."xsd:string |
| http://purl.uniprot.org/citations/31550807 | http://purl.org/dc/terms/identifier | "doi:10.3760/cma.j.issn.0376-2491.2019.36.003"xsd:string |
| http://purl.uniprot.org/citations/31550807 | http://purl.uniprot.org/core/author | "Han Y."xsd:string |
| http://purl.uniprot.org/citations/31550807 | http://purl.uniprot.org/core/author | "Ji J."xsd:string |
| http://purl.uniprot.org/citations/31550807 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/31550807 | http://purl.uniprot.org/core/author | "Shao Z.H."xsd:string |
| http://purl.uniprot.org/citations/31550807 | http://purl.uniprot.org/core/author | "Hua L.M."xsd:string |
| http://purl.uniprot.org/citations/31550807 | http://purl.uniprot.org/core/author | "Pang Y.B."xsd:string |
| http://purl.uniprot.org/citations/31550807 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31550807 | http://purl.uniprot.org/core/name | "Zhonghua Yi Xue Za Zhi"xsd:string |
| http://purl.uniprot.org/citations/31550807 | http://purl.uniprot.org/core/pages | "2811-2815"xsd:string |
| http://purl.uniprot.org/citations/31550807 | http://purl.uniprot.org/core/title | "[Relationship between SHP-1 gene methylation and STAT3 phosphorylation and prognosis in patients with myelodysplastic syndrome]."xsd:string |
| http://purl.uniprot.org/citations/31550807 | http://purl.uniprot.org/core/volume | "99"xsd:string |
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