| http://purl.uniprot.org/citations/31553647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31553647 | http://www.w3.org/2000/01/rdf-schema#comment | "The neonatal Fc receptor (FcRn) has been shown to be required for antigen presentation in dendritic cells, and global knockout of FcRn attenuates immune-mediated kidney disease. Podocytes express interleukin-6 (IL-6) receptor and produce IL-6 under proinflammatory conditions. Here we examined the role of FcRn in the IL-6-mediated inflammatory response in podocytes. We examined IL-6 production by ELISA and expression by qPCR in wild type (WT) and FcRn knockout (KO) podocytes after treatment with proinflammatory stimuli as well as IL-6-mediated signaling via the JAK/STAT pathway. We also examined podocyte motility in cultured WT and KO podocytes after a proinflammatory challenge. We found that FcRn KO podocytes produced minimal amount of IL-6 after treatment with albumin, IgG, or immune complexes whereas WT podocytes had a robust response. FcRn KO podocytes also had minimal expression of IL-6 compared with WT. By Western blotting, there was significantly less phosphorylated STAT3 in KO podocytes after treatment with IFNγ or immune complexes. In a scratch assay, FcRn KO podocytes showed increased motility comparted KO, suggesting a defect in actin dynamics. Cultured FcRn KO podocytes also demonstrated abnormal stress fibers compared with WT and the defect could be rescued by IL-6 treatment. This study shows that in podocytes, FcRn modulates the IL-6 mediated response to proinflammatory stimuli and regulates podocytes actin structure, motility and synaptopodin expression."xsd:string |
| http://purl.uniprot.org/citations/31553647 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpcell.00235.2019"xsd:string |
| http://purl.uniprot.org/citations/31553647 | http://purl.uniprot.org/core/author | "Lewis L."xsd:string |
| http://purl.uniprot.org/citations/31553647 | http://purl.uniprot.org/core/author | "Blaine J."xsd:string |
| http://purl.uniprot.org/citations/31553647 | http://purl.uniprot.org/core/author | "Dylewski J."xsd:string |
| http://purl.uniprot.org/citations/31553647 | http://purl.uniprot.org/core/author | "Tonsawan P."xsd:string |
| http://purl.uniprot.org/citations/31553647 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31553647 | http://purl.uniprot.org/core/name | "Am J Physiol Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/31553647 | http://purl.uniprot.org/core/pages | "C1048-C1060"xsd:string |
| http://purl.uniprot.org/citations/31553647 | http://purl.uniprot.org/core/title | "Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton."xsd:string |
| http://purl.uniprot.org/citations/31553647 | http://purl.uniprot.org/core/volume | "317"xsd:string |
| http://purl.uniprot.org/citations/31553647 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31553647 |
| http://purl.uniprot.org/citations/31553647 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31553647 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GS17-mappedCitation-31553647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31553647 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GSK0-mappedCitation-31553647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31553647 |
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| http://purl.uniprot.org/uniprot/#_Q61559-mappedCitation-31553647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31553647 |
| http://purl.uniprot.org/uniprot/Q6PKB0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31553647 |
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| http://purl.uniprot.org/uniprot/Q61559 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31553647 |
| http://purl.uniprot.org/uniprot/A0A1B0GSK0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31553647 |