| http://purl.uniprot.org/citations/31558435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31558435 | http://www.w3.org/2000/01/rdf-schema#comment | "It has been long appreciated that sex hormone receptors are expressed in various non-gonadal organs. However, it remains unclear how sex hormones regulate the morphogenesis of these non-gonadal organs. To address this issue, we used a male mouse model of androgen-dependent salivary gland morphogenesis. Mice with excessive cholesterol synthesis in the salivary glands exhibited defects in the maturation of granular convoluted tubules (GCTs), which is regulated through sex hormone-dependent cascades. We found that excessive cholesterol synthesis resulted in autophagy failure specifically in the duct cells of salivary glands, followed by the accumulation of NRF2, a transcription factor known as one of the specific substrates for autophagy. The accumulated NRF2 suppressed the expression of Foxa1, which forms a transcriptional complex with the androgen receptor to regulate target genes. Taken together, our results indicate that cholesterol metabolism plays a crucial role in GCT differentiation through autophagy."xsd:string |
| http://purl.uniprot.org/citations/31558435 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.178335"xsd:string |
| http://purl.uniprot.org/citations/31558435 | http://purl.uniprot.org/core/author | "Ogata K."xsd:string |
| http://purl.uniprot.org/citations/31558435 | http://purl.uniprot.org/core/author | "Suzuki A."xsd:string |
| http://purl.uniprot.org/citations/31558435 | http://purl.uniprot.org/core/author | "Yoshioka H."xsd:string |
| http://purl.uniprot.org/citations/31558435 | http://purl.uniprot.org/core/author | "Shim J."xsd:string |
| http://purl.uniprot.org/citations/31558435 | http://purl.uniprot.org/core/author | "Iwata J."xsd:string |
| http://purl.uniprot.org/citations/31558435 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31558435 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/31558435 | http://purl.uniprot.org/core/pages | "dev178335"xsd:string |
| http://purl.uniprot.org/citations/31558435 | http://purl.uniprot.org/core/title | "Cholesterol metabolism plays a crucial role in the regulation of autophagy for cell differentiation of granular convoluted tubules in male mouse submandibular glands."xsd:string |
| http://purl.uniprot.org/citations/31558435 | http://purl.uniprot.org/core/volume | "146"xsd:string |
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