| http://purl.uniprot.org/citations/31558705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31558705 | http://www.w3.org/2000/01/rdf-schema#comment | "Therapeutic applications of tissue-derived mesenchymal stem cells (MSCs) are hindered by their limited expansion ability and variation across donors. Human induced pluripotent stem cell (iPSC)-derived MSCs show greater expandability and therefore offer potential for use in tissue repair therapies. Here we explored the regenerative effects of iPSC-MSCs and the mechanisms by which iPSC-MSCs promote mucosal healing via tumor necrosis factor-α-stimulated gene 6 (TSG-6) in mouse models of inflammatory bowel disease (IBD). Human iPSCs were induced to differentiate into MSCs following a clinically compliant protocol. The iPSC-MSC treatment promoted mucosal healing in colitic mice, accompanied by increased epithelial cell proliferation, CD44-positive cells, and Lgr5-positive cells. TSG-6 knockdown in iPSC-MSCs or blocking of hyaluronan-CD44 interactions by PEP-1 abrogated the therapeutic effects of iPSC-MSCs, whereas use of recombinant TSG-6 showed therapeutic effects similar to those of iPSC-MSCs. A mouse or patient-derived organoid culture system was developed. Organoids co-cultured with iPSC-MSCs showed increased epithelial cell proliferation, CD44-positive cells, and Lgr5-positive cells, which was abolished by TSG-6 knockdown. TSG-6-induced promoting effects in organoids were dependent on Akt activation and abrogated by the anti-CD44 antibody or MK2206. In conclusion, iPSC-MSCs promoted epithelial cell proliferation to accelerate mucosal healing in a murine colitis model via TSG-6 through hyaluronan-CD44 interactions in an Akt-dependent manner, demonstrating a patient-specific "off-the-shelf" format for IBD treatment."xsd:string |
| http://purl.uniprot.org/citations/31558705 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-019-1957-7"xsd:string |
| http://purl.uniprot.org/citations/31558705 | http://purl.uniprot.org/core/author | "Chen M."xsd:string |
| http://purl.uniprot.org/citations/31558705 | http://purl.uniprot.org/core/author | "Feng T."xsd:string |
| http://purl.uniprot.org/citations/31558705 | http://purl.uniprot.org/core/author | "Fu Q."xsd:string |
| http://purl.uniprot.org/citations/31558705 | http://purl.uniprot.org/core/author | "Qiu Y."xsd:string |
| http://purl.uniprot.org/citations/31558705 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/31558705 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/31558705 | http://purl.uniprot.org/core/author | "Xu S."xsd:string |
| http://purl.uniprot.org/citations/31558705 | http://purl.uniprot.org/core/author | "Hao X."xsd:string |
| http://purl.uniprot.org/citations/31558705 | http://purl.uniprot.org/core/author | "Zeng Z."xsd:string |
| http://purl.uniprot.org/citations/31558705 | http://purl.uniprot.org/core/author | "Feng R."xsd:string |
| http://purl.uniprot.org/citations/31558705 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31558705 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/31558705 | http://purl.uniprot.org/core/pages | "718"xsd:string |
| http://purl.uniprot.org/citations/31558705 | http://purl.uniprot.org/core/title | "Human induced pluripotent stem cell-derived mesenchymal stem cells promote healing via TNF-alpha-stimulated gene-6 in inflammatory bowel disease models."xsd:string |
| http://purl.uniprot.org/citations/31558705 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/31558705 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31558705 |
| http://purl.uniprot.org/citations/31558705 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31558705 |
| http://purl.uniprot.org/uniprot/#_P98066-mappedCitation-31558705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31558705 |
| http://purl.uniprot.org/uniprot/P98066 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31558705 |