| http://purl.uniprot.org/citations/31570118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31570118 | http://www.w3.org/2000/01/rdf-schema#comment | "While the sphingosine-1-phosphate (S1P)/sphingosine-1-phosphate receptor-1 (S1PR1) axis is critically important for lymphocyte egress from lymphoid organs, S1PR1-activation also occurs in vascular endothelial cells (ECs), including those of the high-endothelial venules (HEVs) that mediate lymphocyte immigration into lymph nodes (LNs). To understand the functional significance of the S1P/S1PR1-Gi axis in HEVs, we generated Lyve1;Spns2Δ/Δ conditional knockout mice for the S1P-transporter Spinster-homologue-2 (SPNS2), as HEVs express LYVE1 during development. In these mice HEVs appeared apoptotic and were severely impaired in function, morphology and size; leading to markedly hypotrophic peripheral LNs. Dendritic cells (DCs) were unable to interact with HEVs, which was also observed in Cdh5CRE-ERT2;S1pr1Δ/Δ mice and wildtype mice treated with S1PR1-antagonists. Wildtype HEVs treated with S1PR1-antagonists in vitro and Lyve1-deficient HEVs show severely reduced release of the DC-chemoattractant CCL21 in vivo. Together, our results reveal that EC-derived S1P warrants HEV-integrity through autocrine control of S1PR1-Gi signaling, and facilitates concomitant HEV-DC interactions."xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.41239"xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/author | "Aoki J."xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/author | "Inoue A."xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/author | "Sasaki N."xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/author | "Uchida Y."xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/author | "Ishii M."xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/author | "Aoi K."xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/author | "Mochizuki N."xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/author | "Matsuno K."xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/author | "Fukuhara S."xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/author | "Miyasaka M."xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/author | "Umemoto E."xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/author | "Kitazawa Y."xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/author | "Tohya K."xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/author | "Simmons S."xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/author | "Okudaira M."xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/pages | "e41239"xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/title | "High-endothelial cell-derived S1P regulates dendritic cell localization and vascular integrity in the lymph node."xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/31570118 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31570118 |