| http://purl.uniprot.org/citations/31570816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31570816 | http://www.w3.org/2000/01/rdf-schema#comment | "HLA-DRB1 alleles has been found implicated in susceptibility to autoimmune hepatitis (AIH) in populations from different genetic backgrounds. In Mexicans, HLA-DRB1*04:04 is recognized as a risk allele for AIH but, to date, there is no high-resolution data supporting this association. Also, the association of other nonclassical HLA genes, such as TNF-LTA locus, have not, to our knowledge, been evaluated in this population. The association of HLA-DRB1 alleles determined by sequence-based typing and two polymorphisms in the TNF locus with AIH in a sample of Mexican patients was evaluated. Fifty-six patients from Guadalajara, Mexico, diagnosed with AIH and 115 age-gender matched healthy volunteer blood donors, were genotyped for HLA-DRB1 by the sequencing exon 2 and for TNFA-308G>A and LTA + 252A>G polymorphisms. Increased frequencies of both HLA-DRB1*04:04:01 and *16:02:01:01 alleles (OR = 2.91; 95% CI = 1.08-7.84) and the haplotype (DRB1-TNFA-LTA) *04:04:01-G-A (OR = 5.33; 95% CI = 1.32-21.49) were observed in AIH patients. However, after corrections for multiple comparisons, associations were not significant. In conclusion, our study does not support the association of HLA-DRB1*04:04:01 with the susceptibility to AIH in Mexican population. More studies including patients from other Mexican regions and considering other genetic, immunological, and environmental factors should be performed."xsd:string |
| http://purl.uniprot.org/citations/31570816 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41435-019-0086-8"xsd:string |
| http://purl.uniprot.org/citations/31570816 | http://purl.uniprot.org/core/author | "Mendoza-Carrera F."xsd:string |
| http://purl.uniprot.org/citations/31570816 | http://purl.uniprot.org/core/author | "Castro-Martinez X.H."xsd:string |
| http://purl.uniprot.org/citations/31570816 | http://purl.uniprot.org/core/author | "Leal-Cortes C."xsd:string |
| http://purl.uniprot.org/citations/31570816 | http://purl.uniprot.org/core/author | "Davalos-Cobian C."xsd:string |
| http://purl.uniprot.org/citations/31570816 | http://purl.uniprot.org/core/author | "Hernandez-Ramos L.E."xsd:string |
| http://purl.uniprot.org/citations/31570816 | http://purl.uniprot.org/core/author | "Arellano-Olivera M.I.C."xsd:string |
| http://purl.uniprot.org/citations/31570816 | http://purl.uniprot.org/core/author | "Gastelum-Meza M.A."xsd:string |
| http://purl.uniprot.org/citations/31570816 | http://purl.uniprot.org/core/author | "Ramirez-Garcia J."xsd:string |
| http://purl.uniprot.org/citations/31570816 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31570816 | http://purl.uniprot.org/core/name | "Genes Immun"xsd:string |
| http://purl.uniprot.org/citations/31570816 | http://purl.uniprot.org/core/pages | "678-683"xsd:string |
| http://purl.uniprot.org/citations/31570816 | http://purl.uniprot.org/core/title | "No association of HLA-DRB1 and TNF alleles in Mexican patients with autoimmune hepatitis."xsd:string |
| http://purl.uniprot.org/citations/31570816 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/31570816 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31570816 |
| http://purl.uniprot.org/citations/31570816 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31570816 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-31570816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31570816 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-31570816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31570816 |
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| http://purl.uniprot.org/uniprot/#_A0A0E3DD60-mappedCitation-31570816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31570816 |
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