| http://purl.uniprot.org/citations/31573362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31573362 | http://www.w3.org/2000/01/rdf-schema#comment | "Background: Haemorrhagic fever with renal syndrome (HFRS) is characterized by an uncontrolled cytokine storm that causes vascular leakage and kidney injury. The cytokine interleukin 34 (IL-34) enhances proliferation and differentiation of myeloid cells and secretion of pro-inflammatory cytokines, which is involved in the pathogenesis of some inflammatory and infectious diseases, including acute kidney injury. To date, however, the role of IL-34 in patients with HFRS is unclear. This study aims to determine the plasma IL-34 levels of HFRS patients and discuss the possible effects of IL-34 in the pathogenesis of HFRS. Methods: Plasma levels of IL-34 in 52 HFRS patients and 20 healthy controls were quantified using enzyme-linked immunosorbent assay. Results: Compared with healthy controls, the plasma IL-34 levels in HFRS patients were significantly elevated in acute phase [37.92 (0-215.45) pg/ml vs. 7.13 (0-19.44) pg/ml, p < .0001], and then decreased to the normal levels in convalescent phase. Importantly, IL-34 levels correlated positively with white blood cell counts and mononuclear cell counts (r = 0.592, p < .0001 and r = 0.458, p < .0001, respectively), and correlated negatively with platelet counts and serum albumin levels (r = -0.430, p < .0001 and r = -0.479, p = .0001, respectively). Conclusions: Plasma levels of IL-34 in HFRS patients were significantly elevated in acute phase and correlated with disease severity-reflecting parameters, which suggests a potential role of IL-34 in HFRS and should be future explored."xsd:string |
| http://purl.uniprot.org/citations/31573362 | http://purl.org/dc/terms/identifier | "doi:10.1080/23744235.2019.1672887"xsd:string |
| http://purl.uniprot.org/citations/31573362 | http://purl.uniprot.org/core/author | "Du H."xsd:string |
| http://purl.uniprot.org/citations/31573362 | http://purl.uniprot.org/core/author | "Ma Y."xsd:string |
| http://purl.uniprot.org/citations/31573362 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/31573362 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/31573362 | http://purl.uniprot.org/core/author | "Zhang Y.'"xsd:string |
| http://purl.uniprot.org/citations/31573362 | http://purl.uniprot.org/core/author | "Tang K."xsd:string |
| http://purl.uniprot.org/citations/31573362 | http://purl.uniprot.org/core/author | "Jin B."xsd:string |
| http://purl.uniprot.org/citations/31573362 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31573362 | http://purl.uniprot.org/core/name | "Infect Dis (Lond)"xsd:string |
| http://purl.uniprot.org/citations/31573362 | http://purl.uniprot.org/core/pages | "847-853"xsd:string |
| http://purl.uniprot.org/citations/31573362 | http://purl.uniprot.org/core/title | "Elevated plasma interleukin 34 levels correlate with disease severity-reflecting parameters of patients with haemorrhagic fever with renal syndrome."xsd:string |
| http://purl.uniprot.org/citations/31573362 | http://purl.uniprot.org/core/volume | "51"xsd:string |
| http://purl.uniprot.org/citations/31573362 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31573362 |
| http://purl.uniprot.org/citations/31573362 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31573362 |
| http://purl.uniprot.org/uniprot/#_Q6ZMJ4-mappedCitation-31573362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31573362 |
| http://purl.uniprot.org/uniprot/Q6ZMJ4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31573362 |